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Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract.
Zhang J, Walker ME, Sanidad KZ, Zhang H, Liang Y, Zhao E, Chacon-Vargas K, Yeliseyev V, Parsonnet J, Haggerty TD, Wang G, Simpson JB, Jariwala PB, Beaty VV, Yang J, Yang H, Panigrahy A, Minter LM, Kim D, Gibbons JG, Liu L, Li Z, Xiao H, Borlandelli V, Overkleeft HS, Cloer EW, Major MB, Goldfarb D, Cai Z, Redinbo MR, Zhang G. Zhang J, et al. Among authors: redinbo mr. Nat Commun. 2022 Jan 10;13(1):136. doi: 10.1038/s41467-021-27762-y. Nat Commun. 2022. PMID: 35013263 Free PMC article.
Discovering the Microbial Enzymes Driving Drug Toxicity with Activity-Based Protein Profiling.
Jariwala PB, Pellock SJ, Goldfarb D, Cloer EW, Artola M, Simpson JB, Bhatt AP, Walton WG, Roberts LR, Major MB, Davies GJ, Overkleeft HS, Redinbo MR. Jariwala PB, et al. Among authors: redinbo mr. ACS Chem Biol. 2020 Jan 17;15(1):217-225. doi: 10.1021/acschembio.9b00788. Epub 2019 Dec 12. ACS Chem Biol. 2020. PMID: 31774274 Free PMC article.
Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy.
Bhatt AP, Pellock SJ, Biernat KA, Walton WG, Wallace BD, Creekmore BC, Letertre MM, Swann JR, Wilson ID, Roques JR, Darr DB, Bailey ST, Montgomery SA, Roach JM, Azcarate-Peril MA, Sartor RB, Gharaibeh RZ, Bultman SJ, Redinbo MR. Bhatt AP, et al. Among authors: redinbo mr. Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7374-7381. doi: 10.1073/pnas.1918095117. Epub 2020 Mar 13. Proc Natl Acad Sci U S A. 2020. PMID: 32170007 Free PMC article.
Gut microbial β-glucuronidases regulate host luminal proteases and are depleted in irritable bowel syndrome.
Edwinson AL, Yang L, Peters S, Hanning N, Jeraldo P, Jagtap P, Simpson JB, Yang TY, Kumar P, Mehta S, Nair A, Breen-Lyles M, Chikkamenahalli L, Graham RP, De Winter B, Patel R, Dasari S, Kashyap P, Griffin T, Chen J, Farrugia G, Redinbo MR, Grover M. Edwinson AL, et al. Among authors: redinbo mr. Nat Microbiol. 2022 May;7(5):680-694. doi: 10.1038/s41564-022-01103-1. Epub 2022 Apr 28. Nat Microbiol. 2022. PMID: 35484230 Free PMC article.
161 results