Reddy MB - Search Results

1

PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5'-Diphospho-glucuronosyltransferase Substrates.

Reddy MB, Bolger MB, Fraczkiewicz G, Del Frari L, Luo L, Lukacova V, Mitra A, Macwan JS, Mullin JM, Parrott N, Heikkinen AT. Reddy MB, et al. Pharmaceutics. 2021 Aug 24;13(9):1325. doi: 10.3390/pharmaceutics13091325. Pharmaceutics. 2021. PMID: 34575401 Free PMC article. Review.

2

Physiologically Based Pharmacokinetic Modelling for First-In-Human Predictions: An Updated Model Building Strategy Illustrated with Challenging Industry Case Studies.

Miller NA, Reddy MB, Heikkinen AT, Lukacova V, Parrott N. Miller NA, et al. Among authors: reddy mb. Clin Pharmacokinet. 2019 Jun;58(6):727-746. doi: 10.1007/s40262-019-00741-9. Clin Pharmacokinet. 2019. PMID: 30729397 Review.

3

A Physiologically Based Pharmacokinetic Model for Ganciclovir and Its Prodrug Valganciclovir in Adults and Children.

Lukacova V, Goelzer P, Reddy M, Greig G, Reigner B, Parrott N. Lukacova V, et al. AAPS J. 2016 Nov;18(6):1453-1463. doi: 10.1208/s12248-016-9956-4. Epub 2016 Jul 22. AAPS J. 2016. PMID: 27450227

4

Current Practices, Gap Analysis, and Proposed Workflows for PBPK Modeling of Cytochrome P450 Induction: An Industry Perspective.

Hariparsad N, Ramsden D, Taskar K, Badée J, Venkatakrishnan K, Reddy MB, Cabalu T, Mukherjee D, Rehmel J, Bolleddula J, Emami Riedmaier A, Prakash C, Chanteux H, Mao J, Umehara K, Shah K, De Zwart L, Dowty M, Kotsuma M, Li M, Pilla Reddy V, McGinnity DF, Parrott N. Hariparsad N, et al. Among authors: reddy mb. Clin Pharmacol Ther. 2022 Oct;112(4):770-781. doi: 10.1002/cpt.2503. Epub 2021 Dec 24. Clin Pharmacol Ther. 2022. PMID: 34862964

5

Investigating the effect of autoinduction in cynomolgus monkeys of a novel anticancer MDM2 antagonist, idasanutlin, and relevance to humans.

Glenn KJ, Yu LJ, Reddy MB, Fretland AJ, Parrott N, Hussain S, Palacios M, Vazvaei F, Zhi J, Tuerck D. Glenn KJ, et al. Among authors: reddy mb. Xenobiotica. 2016 Aug;46(8):667-76. doi: 10.3109/00498254.2015.1110761. Epub 2015 Nov 19. Xenobiotica. 2016. PMID: 26586447

6

Challenges and opportunities with modelling and simulation in drug discovery and drug development.

Lavé T, Parrott N, Grimm HP, Fleury A, Reddy M. Lavé T, et al. Xenobiotica. 2007 Oct-Nov;37(10-11):1295-310. doi: 10.1080/00498250701534885. Xenobiotica. 2007. PMID: 17968746

7

Pharmacokinetic/Pharmacodynamic predictors of clinical potency for hepatitis C virus nonnucleoside polymerase and protease inhibitors.

Reddy MB, Morcos PN, Le Pogam S, Ou Y, Frank K, Lave T, Smith P. Reddy MB, et al. Antimicrob Agents Chemother. 2012 Jun;56(6):3144-56. doi: 10.1128/AAC.06283-11. Epub 2012 Apr 2. Antimicrob Agents Chemother. 2012. PMID: 22470110 Free PMC article.

8

Differential analysis of transient increases of serum cTnI in response to handling in rats.

Mikaelian I, Dunn ME, Mould DR, Hirkaler G, Geng W, Coluccio D, Nicklaus R, Singer T, Reddy M. Mikaelian I, et al. Pharmacol Res Perspect. 2013 Dec;1(2):e00011. doi: 10.1002/prp2.11. Epub 2013 Dec 5. Pharmacol Res Perspect. 2013. PMID: 25505566 Free PMC article.

9

Impact of low-dose ritonavir on danoprevir pharmacokinetics: results of computer-based simulations and a clinical drug-drug interaction study.

Reddy MB, Chen Y, Haznedar JO, Fretland J, Blotner S, Smith P, Tran JQ. Reddy MB, et al. Clin Pharmacokinet. 2012 Jul 1;51(7):457-65. doi: 10.2165/11599700-000000000-00000. Clin Pharmacokinet. 2012. PMID: 22624502 Clinical Trial.

10

A next-generation BRAF inhibitor overcomes resistance to BRAF inhibition in patients with BRAF-mutant cancers using pharmacokinetics-informed dose escalation.

Yaeger R, McKean MA, Haq R, Beck JT, Taylor MH, Cohen JE, Bowles DW, Gadgeel SM, Mihalcioiu C, Papadopoulos KP, Diamond EL, Sturtz KB, Feng G, Drescher SK, Reddy MB, Sengupta B, Maity AK, Brown SA, Singh A, Brown EN, Baer BR, Wong J, Mou TC, Wu WI, Kahn DR, Gadal S, Rosen N, Gaudino JJ, Lee PA, Hartley DP, Rothenberg SM. Yaeger R, et al. Among authors: reddy mb. Cancer Discov. 2024 Apr 30. doi: 10.1158/2159-8290.CD-24-0024. Online ahead of print. Cancer Discov. 2024. PMID: 38691346

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