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Safety and efficacy of laquinimod for Huntington's disease (LEGATO-HD): a multicentre, randomised, double-blind, placebo-controlled, phase 2 study.
Reilmann R, Anderson KE, Feigin A, Tabrizi SJ, Leavitt BR, Stout JC, Piccini P, Schubert R, Loupe P, Wickenberg A, Borowsky B, Rynkowski G, Volkinshtein R, Li T, Savola JM, Hayden M, Gordon MF; LEGATO-HD Study Group. Reilmann R, et al. Lancet Neurol. 2024 Mar;23(3):243-255. doi: 10.1016/S1474-4422(23)00454-4. Epub 2024 Jan 24. Lancet Neurol. 2024. PMID: 38280392 Clinical Trial.
Huntington's disease has a chronic and slowly progressive course, and this study does not address whether a longer duration of laquinimod treatment could have produced detectable and meaningful changes in the clinical assessments. ...
Huntington's disease has a chronic and slowly progressive course, and this study does not address whether a longer duration of laquin …
Water-Reaching Platform for Longitudinal Assessment of Cortical Activity and Fine Motor Coordination Defects in a Huntington Disease Mouse Model.
Wang Y, Sepers MD, Xiao D, Raymond LA, Murphy TH. Wang Y, et al. Among authors: raymond la. eNeuro. 2023 Jan 9;10(1):ENEURO.0452-22.2022. doi: 10.1523/ENEURO.0452-22.2022. Print 2023 Jan. eNeuro. 2023. PMID: 36596592 Free PMC article.
Behavioral analysis of the water-reaching task reveals that HD mice, despite learning the water-reaching task as proficiently as wild-type mice, take longer to learn the alternating event sequence as evident by impulsive (noncued) reaches and initially display reduced cort …
Behavioral analysis of the water-reaching task reveals that HD mice, despite learning the water-reaching task as proficiently as wild-type m …
Histone Lysine Methylases and Demethylases in the Landscape of Human Developmental Disorders.
Faundes V, Newman WG, Bernardini L, Canham N, Clayton-Smith J, Dallapiccola B, Davies SJ, Demos MK, Goldman A, Gill H, Horton R, Kerr B, Kumar D, Lehman A, McKee S, Morton J, Parker MJ, Rankin J, Robertson L, Temple IK; Clinical Assessment of the Utility of Sequencing and Evaluation as a Service (CAUSES) Study; Deciphering Developmental Disorders (DDD) Study; Banka S. Faundes V, et al. Am J Hum Genet. 2018 Jan 4;102(1):175-187. doi: 10.1016/j.ajhg.2017.11.013. Epub 2017 Dec 21. Am J Hum Genet. 2018. PMID: 29276005 Free PMC article.
We show that KMTs and KDMs that are associated with, or are candidates for, dominant developmental disorders tend to have a higher level of transcription, longer canonical transcripts, more interactors, and a higher number and more types of post-translational modifications …
We show that KMTs and KDMs that are associated with, or are candidates for, dominant developmental disorders tend to have a higher level of …
An Automated Home-Cage System to Assess Learning and Performance of a Skilled Motor Task in a Mouse Model of Huntington's Disease.
Woodard CL, Bolaños F, Boyd JD, Silasi G, Murphy TH, Raymond LA. Woodard CL, et al. Among authors: raymond la. eNeuro. 2017 Sep 18;4(5):ENEURO.0141-17.2017. doi: 10.1523/ENEURO.0141-17.2017. eCollection 2017 Sep-Oct. eNeuro. 2017. PMID: 28929129 Free PMC article.
Animals first acquire a simple operant response, before moving to a second phase where they must learn to hold the lever for progressively longer in a rewarded position range. Testing with this paradigm has revealed the presence of distinct phenotypes in the YAC128 mouse m …
Animals first acquire a simple operant response, before moving to a second phase where they must learn to hold the lever for progressively …
Prion Protein Prolines 102 and 105 and the Surrounding Lysine Cluster Impede Amyloid Formation.
Kraus A, Anson KJ, Raymond LD, Martens C, Groveman BR, Dorward DW, Caughey B. Kraus A, et al. Among authors: raymond ld. J Biol Chem. 2015 Aug 28;290(35):21510-22. doi: 10.1074/jbc.M115.665844. Epub 2015 Jul 14. J Biol Chem. 2015. PMID: 26175152 Free PMC article.
Substitution of these proline and lysine residues accelerated PrP conversion such that spontaneous amyloid formation was no longer slower than scrapie-seeded amyloid formation. Thus, Pro-102 and Pro-105, as well as the lysines in the central lysine cluster, impede amyloid …
Substitution of these proline and lysine residues accelerated PrP conversion such that spontaneous amyloid formation was no longer sl …
Comorbidities of obsessive and compulsive symptoms in Huntington's disease.
Anderson KE, Gehl CR, Marder KS, Beglinger LJ, Paulsen JS; Huntington's Study Group. Anderson KE, et al. J Nerv Ment Dis. 2010 May;198(5):334-8. doi: 10.1097/NMD.0b013e3181da852a. J Nerv Ment Dis. 2010. PMID: 20458194 Free PMC article.
Individuals with HD and O/Cs were older, had poorer functioning, and a longer duration of illness than those without O/Cs. Individuals with HD and O/Cs endorsed significantly higher psychiatric comorbidities of depression, suicidal ideation, aggression, delusions, and hall …
Individuals with HD and O/Cs were older, had poorer functioning, and a longer duration of illness than those without O/Cs. Individual …
Cobratoxin inhibits pain-evoked discharge of neurons in thalamic parafascicular nucleus in rats: involvement of cholinergic and serotonergic systems.
Cheng BC, Zhou XP, Zhu Q, Gong S, Qin ZH, Reid PF, Raymond LN, Yin QZ, Jiang XH. Cheng BC, et al. Among authors: raymond ln. Toxicon. 2009 Sep 1;54(3):224-32. doi: 10.1016/j.toxicon.2009.04.007. Epub 2009 Apr 16. Toxicon. 2009. PMID: 19375445
The inhibition of pain-evoked discharges of Pf neurons by CTX at high dose (4.50 microg/kg) persisted at least for 2h, while the inhibitory effect of morphine (40 microg) persisted no longer than 30 min. The inhibitory effect of CTX was reversed by pretreatment with atropi …
The inhibition of pain-evoked discharges of Pf neurons by CTX at high dose (4.50 microg/kg) persisted at least for 2h, while the inhibitory …
Nurse practitioner services: three-year impact on health care costs.
Chenoweth D, Martin N, Pankowski J, Raymond LW. Chenoweth D, et al. Among authors: raymond lw. J Occup Environ Med. 2008 Nov;50(11):1293-8. doi: 10.1097/JOM.0b013e318184563a. J Occup Environ Med. 2008. PMID: 19001955
CONCLUSIONS: This 3-year analysis confirms our preliminary findings that an on-site NP has a favorable benefit-to-cost function. Longer-term analyses are needed to confirm these findings....
CONCLUSIONS: This 3-year analysis confirms our preliminary findings that an on-site NP has a favorable benefit-to-cost function. Longer …
A benefit-cost analysis of a worksite nurse practitioner program: first impressions.
Chenoweth D, Martin N, Pankowski J, Raymond LW. Chenoweth D, et al. Among authors: raymond lw. J Occup Environ Med. 2005 Nov;47(11):1110-6. doi: 10.1097/01.jom.0000182093.48440.4c. J Occup Environ Med. 2005. PMID: 16282871
CONCLUSIONS: The first 6 months of a new NP initiative yielded substantial reductions in HCC that warrant further analysis over longer periods of observation. However, the initial estimates may understate the aggregate value of the program because it may also reduce on-sit …
CONCLUSIONS: The first 6 months of a new NP initiative yielded substantial reductions in HCC that warrant further analysis over longer …
Changes in agonist concentration dependence that are a function of duration of exposure suggest N-methyl-D-aspartate receptor nonsaturation during synaptic stimulation.
Chen N, Ren J, Raymond LA, Murphy TH. Chen N, et al. Among authors: raymond la. Mol Pharmacol. 2001 Feb;59(2):212-9. doi: 10.1124/mol.59.2.212. Mol Pharmacol. 2001. PMID: 11160855
However, at 37 degrees C, we still observed a significant increase in potency with longer agonist application duration. We propose that glutamate has a relatively lower potency at NMDARs than previously thought from agonist application under equilibrium conditions. ...
However, at 37 degrees C, we still observed a significant increase in potency with longer agonist application duration. We propose th …
13 results