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α-Synuclein aggregation nucleates through liquid-liquid phase separation.
Ray S, Singh N, Kumar R, Patel K, Pandey S, Datta D, Mahato J, Panigrahi R, Navalkar A, Mehra S, Gadhe L, Chatterjee D, Sawner AS, Maiti S, Bhatia S, Gerez JA, Chowdhury A, Kumar A, Padinhateeri R, Riek R, Krishnamoorthy G, Maji SK. Ray S, et al. Nat Chem. 2020 Aug;12(8):705-716. doi: 10.1038/s41557-020-0465-9. Epub 2020 Jun 8. Nat Chem. 2020. PMID: 32514159
Comparison of Kinetics, Toxicity, Oligomer Formation, and Membrane Binding Capacity of α-Synuclein Familial Mutations at the A53 Site, Including the Newly Discovered A53V Mutation.
Mohite GM, Kumar R, Panigrahi R, Navalkar A, Singh N, Datta D, Mehra S, Ray S, Gadhe LG, Das S, Singh N, Chatterjee D, Kumar A, Maji SK. Mohite GM, et al. Among authors: ray s. Biochemistry. 2018 Sep 4;57(35):5183-5187. doi: 10.1021/acs.biochem.8b00314. Epub 2018 May 21. Biochemistry. 2018. PMID: 29771508
Glycosaminoglycans have variable effects on α-synuclein aggregation and differentially affect the activities of the resulting amyloid fibrils.
Mehra S, Ghosh D, Kumar R, Mondal M, Gadhe LG, Das S, Anoop A, Jha NN, Jacob RS, Chatterjee D, Ray S, Singh N, Kumar A, Maji SK. Mehra S, et al. Among authors: ray s. J Biol Chem. 2018 Aug 24;293(34):12975-12991. doi: 10.1074/jbc.RA118.004267. Epub 2018 Jun 29. J Biol Chem. 2018. PMID: 29959225 Free PMC article.
Predictable phase-separated proteins.
Ray S, Maji SK. Ray S, et al. Nat Chem. 2020 Sep;12(9):787-789. doi: 10.1038/s41557-020-0532-2. Nat Chem. 2020. PMID: 32807882 No abstract available.
Effect of Disease-Associated P123H and V70M Mutations on β-Synuclein Fibrillation.
Sharma K, Mehra S, Sawner AS, Markam PS, Panigrahi R, Navalkar A, Chatterjee D, Kumar R, Kadu P, Patel K, Ray S, Kumar A, Maji SK. Sharma K, et al. Among authors: ray s. ACS Chem Neurosci. 2020 Sep 16;11(18):2836-2848. doi: 10.1021/acschemneuro.0c00405. Epub 2020 Sep 6. ACS Chem Neurosci. 2020. PMID: 32833434
Modulating α-Synuclein Liquid-Liquid Phase Separation.
Sawner AS, Ray S, Yadav P, Mukherjee S, Panigrahi R, Poudyal M, Patel K, Ghosh D, Kummerant E, Kumar A, Riek R, Maji SK. Sawner AS, et al. Among authors: ray s. Biochemistry. 2021 Dec 7;60(48):3676-3696. doi: 10.1021/acs.biochem.1c00434. Epub 2021 Aug 25. Biochemistry. 2021. PMID: 34431665
4,610 results