A novel synthetic analogue of ω-3 17,18-epoxyeicosatetraenoic acid activates TNF receptor-1/ASK1/JNK signaling to promote apoptosis in human breast cancer cells.
Dyari HRE, Rawling T, Chen Y, Sudarmana W, Bourget K, Dwyer JM, Allison SE, Murray M.
Dyari HRE, et al. Among authors: rawling t.
FASEB J. 2017 Dec;31(12):5246-5257. doi: 10.1096/fj.201700033R. Epub 2017 Aug 10.
FASEB J. 2017.
PMID: 28798154
In in vivo studies, tumors isolated from C20E-treated nu/nu mice carrying MDA-MB-231 xenografts showed increased TUNEL staining and decreased Ki67 staining, reflecting increased apoptosis and decreased proliferation, respectively. omega-3-Epoxy fatty acids like C20E could be inco …
In in vivo studies, tumors isolated from C20E-treated nu/nu mice carrying MDA-MB-231 xenografts showed increased TUNEL staining and decrease …