Rauh D - Search Results

1

Fragtory: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp³-Enriched Fragment Library.

Bührmann M, Kallepu S, Warmuth JD, Wiese JN, Ehrt C, Vatheuer H, Hiller W, Seitz C, Levy L, Czodrowski P, Sievers S, Müller MP, Rauh D. Bührmann M, et al. Among authors: rauh d. J Med Chem. 2023 May 11;66(9):6297-6314. doi: 10.1021/acs.jmedchem.3c00187. Epub 2023 May 2. J Med Chem. 2023. PMID: 37130057

2

Displacement assay for the detection of stabilizers of inactive kinase conformations.

Klüter S, Grütter C, Naqvi T, Rabiller M, Simard JR, Pawar V, Getlik M, Rauh D. Klüter S, et al. Among authors: rauh d. J Med Chem. 2010 Jan 14;53(1):357-67. doi: 10.1021/jm901297e. J Med Chem. 2010. PMID: 19928858

3

Synthesis and biological evaluation of 4-anilinoquinolines as potent inhibitors of epidermal growth factor receptor.

Pawar VG, Sos ML, Rode HB, Rabiller M, Heynck S, van Otterlo WA, Thomas RK, Rauh D. Pawar VG, et al. Among authors: rauh d. J Med Chem. 2010 Apr 8;53(7):2892-901. doi: 10.1021/jm901877j. J Med Chem. 2010. PMID: 20222733

4

Structure-based design, synthesis and biological evaluation of N-pyrazole, N'-thiazole urea inhibitors of MAP kinase p38α.

Getlik M, Grütter C, Simard JR, Nguyen HD, Robubi A, Aust B, van Otterlo WA, Rauh D. Getlik M, et al. Among authors: rauh d. Eur J Med Chem. 2012 Feb;48:1-15. doi: 10.1016/j.ejmech.2011.11.019. Epub 2011 Nov 18. Eur J Med Chem. 2012. PMID: 22154891

5

Natural-product-derived fragments for fragment-based ligand discovery.

Over B, Wetzel S, Grütter C, Nakai Y, Renner S, Rauh D, Waldmann H. Over B, et al. Among authors: rauh d. Nat Chem. 2013 Jan;5(1):21-8. doi: 10.1038/nchem.1506. Epub 2012 Dec 2. Nat Chem. 2013. PMID: 23247173

6

Highly enantioselective catalytic synthesis of neurite growth-promoting secoyohimbanes.

Antonchick AP, López-Tosco S, Parga J, Sievers S, Schürmann M, Preut H, Höing S, Schöler HR, Sterneckert J, Rauh D, Waldmann H. Antonchick AP, et al. Among authors: rauh d. Chem Biol. 2013 Apr 18;20(4):500-9. doi: 10.1016/j.chembiol.2013.03.011. Chem Biol. 2013. PMID: 23601639

7

Targeting gain of function and resistance mutations in Abl and KIT by hybrid compound design.

Richters A, Ketzer J, Getlik M, Grütter C, Schneider R, Heuckmann JM, Heynck S, Sos ML, Gupta A, Unger A, Schultz-Fademrecht C, Thomas RK, Bauer S, Rauh D. Richters A, et al. Among authors: rauh d. J Med Chem. 2013 Jul 25;56(14):5757-72. doi: 10.1021/jm4004076. Epub 2013 Jul 10. J Med Chem. 2013. PMID: 23773153

8

Identification of type II and III DDR2 inhibitors.

Richters A, Nguyen HD, Phan T, Simard JR, Grütter C, Engel J, Rauh D. Richters A, et al. Among authors: rauh d. J Med Chem. 2014 May 22;57(10):4252-62. doi: 10.1021/jm500167q. Epub 2014 May 5. J Med Chem. 2014. PMID: 24754677

9

Structure-based design and synthesis of covalent-reversible inhibitors to overcome drug resistance in EGFR.

Basu D, Richters A, Rauh D. Basu D, et al. Among authors: rauh d. Bioorg Med Chem. 2015 Jun 15;23(12):2767-80. doi: 10.1016/j.bmc.2015.04.038. Epub 2015 Apr 23. Bioorg Med Chem. 2015. PMID: 25975640

10

Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach.

Engel J, Richters A, Getlik M, Tomassi S, Keul M, Termathe M, Lategahn J, Becker C, Mayer-Wrangowski S, Grütter C, Uhlenbrock N, Krüll J, Schaumann N, Eppmann S, Kibies P, Hoffgaard F, Heil J, Menninger S, Ortiz-Cuaran S, Heuckmann JM, Tinnefeld V, Zahedi RP, Sos ML, Schultz-Fademrecht C, Thomas RK, Kast SM, Rauh D. Engel J, et al. Among authors: rauh d. J Med Chem. 2015 Sep 10;58(17):6844-63. doi: 10.1021/acs.jmedchem.5b01082. Epub 2015 Aug 31. J Med Chem. 2015. PMID: 26275028

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