Rauh D - Search Results

1

Optimization of Covalent MKK7 Inhibitors via Crude Nanomole-Scale Libraries.

Gehrtz P, Marom S, Bührmann M, Hardick J, Kleinbölting S, Shraga A, Dubiella C, Gabizon R, Wiese JN, Müller MP, Cohen G, Babaev I, Shurrush K, Avram L, Resnick E, Barr H, Rauh D, London N. Gehrtz P, et al. Among authors: rauh d. J Med Chem. 2022 Aug 11;65(15):10341-10356. doi: 10.1021/acs.jmedchem.1c02206. Epub 2022 Jul 30. J Med Chem. 2022. PMID: 35912476 Free PMC article.

2

Displacement assay for the detection of stabilizers of inactive kinase conformations.

Klüter S, Grütter C, Naqvi T, Rabiller M, Simard JR, Pawar V, Getlik M, Rauh D. Klüter S, et al. Among authors: rauh d. J Med Chem. 2010 Jan 14;53(1):357-67. doi: 10.1021/jm901297e. J Med Chem. 2010. PMID: 19928858

3

Synthesis and biological evaluation of 4-anilinoquinolines as potent inhibitors of epidermal growth factor receptor.

Pawar VG, Sos ML, Rode HB, Rabiller M, Heynck S, van Otterlo WA, Thomas RK, Rauh D. Pawar VG, et al. Among authors: rauh d. J Med Chem. 2010 Apr 8;53(7):2892-901. doi: 10.1021/jm901877j. J Med Chem. 2010. PMID: 20222733

4

Synthesis and biological evaluation of 7-substituted-1-(3-bromophenylamino)isoquinoline-4-carbonitriles as inhibitors of myosin light chain kinase and epidermal growth factor receptor.

Rode HB, Sos ML, Grütter C, Heynck S, Simard JR, Rauh D. Rode HB, et al. Among authors: rauh d. Bioorg Med Chem. 2011 Jan 1;19(1):429-39. doi: 10.1016/j.bmc.2010.11.007. Epub 2010 Nov 10. Bioorg Med Chem. 2011. PMID: 21130659

5

Structure-based design, synthesis and biological evaluation of N-pyrazole, N'-thiazole urea inhibitors of MAP kinase p38α.

Getlik M, Grütter C, Simard JR, Nguyen HD, Robubi A, Aust B, van Otterlo WA, Rauh D. Getlik M, et al. Among authors: rauh d. Eur J Med Chem. 2012 Feb;48:1-15. doi: 10.1016/j.ejmech.2011.11.019. Epub 2011 Nov 18. Eur J Med Chem. 2012. PMID: 22154891

6

Identification of type II and III DDR2 inhibitors.

Richters A, Nguyen HD, Phan T, Simard JR, Grütter C, Engel J, Rauh D. Richters A, et al. Among authors: rauh d. J Med Chem. 2014 May 22;57(10):4252-62. doi: 10.1021/jm500167q. Epub 2014 May 5. J Med Chem. 2014. PMID: 24754677

7

Structure-based design and synthesis of covalent-reversible inhibitors to overcome drug resistance in EGFR.

Basu D, Richters A, Rauh D. Basu D, et al. Among authors: rauh d. Bioorg Med Chem. 2015 Jun 15;23(12):2767-80. doi: 10.1016/j.bmc.2015.04.038. Epub 2015 Apr 23. Bioorg Med Chem. 2015. PMID: 25975640

8

Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach.

Engel J, Richters A, Getlik M, Tomassi S, Keul M, Termathe M, Lategahn J, Becker C, Mayer-Wrangowski S, Grütter C, Uhlenbrock N, Krüll J, Schaumann N, Eppmann S, Kibies P, Hoffgaard F, Heil J, Menninger S, Ortiz-Cuaran S, Heuckmann JM, Tinnefeld V, Zahedi RP, Sos ML, Schultz-Fademrecht C, Thomas RK, Kast SM, Rauh D. Engel J, et al. Among authors: rauh d. J Med Chem. 2015 Sep 10;58(17):6844-63. doi: 10.1021/acs.jmedchem.5b01082. Epub 2015 Aug 31. J Med Chem. 2015. PMID: 26275028

9

Hope and Disappointment: Covalent Inhibitors to Overcome Drug Resistance in Non-Small Cell Lung Cancer.

Engel J, Lategahn J, Rauh D. Engel J, et al. Among authors: rauh d. ACS Med Chem Lett. 2015 Dec 18;7(1):2-5. doi: 10.1021/acsmedchemlett.5b00475. eCollection 2016 Jan 14. ACS Med Chem Lett. 2015. PMID: 26819655 Free PMC article.

10

Indazole-Based Covalent Inhibitors To Target Drug-Resistant Epidermal Growth Factor Receptor.

Tomassi S, Lategahn J, Engel J, Keul M, Tumbrink HL, Ketzer J, Mühlenberg T, Baumann M, Schultz-Fademrecht C, Bauer S, Rauh D. Tomassi S, et al. Among authors: rauh d. J Med Chem. 2017 Mar 23;60(6):2361-2372. doi: 10.1021/acs.jmedchem.6b01626. Epub 2017 Mar 10. J Med Chem. 2017. PMID: 28225269

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