Rauh D - Search Results

1

Design, Synthesis, and Biological Evaluation of Novel Type I¹/₂ p38α MAP Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target Residence Time by Interfering with the R-Spine.

Walter NM, Wentsch HK, Bührmann M, Bauer SM, Döring E, Mayer-Wrangowski S, Sievers-Engler A, Willemsen-Seegers N, Zaman G, Buijsman R, Lämmerhofer M, Rauh D, Laufer SA. Walter NM, et al. Among authors: rauh d. J Med Chem. 2017 Oct 12;60(19):8027-8054. doi: 10.1021/acs.jmedchem.7b00745. Epub 2017 Sep 7. J Med Chem. 2017. PMID: 28834431

2

Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR.

Michalczyk A, Klüter S, Rode HB, Simard JR, Grütter C, Rabiller M, Rauh D. Michalczyk A, et al. Among authors: rauh d. Bioorg Med Chem. 2008 Apr 1;16(7):3482-8. doi: 10.1016/j.bmc.2008.02.053. Epub 2008 Feb 20. Bioorg Med Chem. 2008. PMID: 18316192

3

ATP competitive inhibitors of D-alanine-D-alanine ligase based on protein kinase inhibitor scaffolds.

Triola G, Wetzel S, Ellinger B, Koch MA, Hübel K, Rauh D, Waldmann H. Triola G, et al. Among authors: rauh d. Bioorg Med Chem. 2009 Feb 1;17(3):1079-87. doi: 10.1016/j.bmc.2008.02.046. Epub 2008 Feb 16. Bioorg Med Chem. 2009. PMID: 18321716

4

Hybrid compound design to overcome the gatekeeper T338M mutation in cSrc.

Getlik M, Grütter C, Simard JR, Klüter S, Rabiller M, Rode HB, Robubi A, Rauh D. Getlik M, et al. Among authors: rauh d. J Med Chem. 2009 Jul 9;52(13):3915-26. doi: 10.1021/jm9002928. J Med Chem. 2009. PMID: 19462975

5

Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors.

Simard JR, Getlik M, Grütter C, Pawar V, Wulfert S, Rabiller M, Rauh D. Simard JR, et al. Among authors: rauh d. J Am Chem Soc. 2009 Sep 23;131(37):13286-96. doi: 10.1021/ja902010p. J Am Chem Soc. 2009. PMID: 19572644

6

Displacement assay for the detection of stabilizers of inactive kinase conformations.

Klüter S, Grütter C, Naqvi T, Rabiller M, Simard JR, Pawar V, Getlik M, Rauh D. Klüter S, et al. Among authors: rauh d. J Med Chem. 2010 Jan 14;53(1):357-67. doi: 10.1021/jm901297e. J Med Chem. 2010. PMID: 19928858

7

High-throughput screening to identify inhibitors which stabilize inactive kinase conformations in p38alpha.

Simard JR, Grütter C, Pawar V, Aust B, Wolf A, Rabiller M, Wulfert S, Robubi A, Klüter S, Ottmann C, Rauh D. Simard JR, et al. Among authors: rauh d. J Am Chem Soc. 2009 Dec 30;131(51):18478-88. doi: 10.1021/ja907795q. J Am Chem Soc. 2009. PMID: 19950957

8

Fluorophore labeling of the glycine-rich loop as a method of identifying inhibitors that bind to active and inactive kinase conformations.

Simard JR, Getlik M, Grütter C, Schneider R, Wulfert S, Rauh D. Simard JR, et al. Among authors: rauh d. J Am Chem Soc. 2010 Mar 31;132(12):4152-60. doi: 10.1021/ja908083e. J Am Chem Soc. 2010. PMID: 20201574

9

Synthesis and biological evaluation of 4-anilinoquinolines as potent inhibitors of epidermal growth factor receptor.

Pawar VG, Sos ML, Rode HB, Rabiller M, Heynck S, van Otterlo WA, Thomas RK, Rauh D. Pawar VG, et al. Among authors: rauh d. J Med Chem. 2010 Apr 8;53(7):2892-901. doi: 10.1021/jm901877j. J Med Chem. 2010. PMID: 20222733

10

Synthesis and biological evaluation of 7-substituted-1-(3-bromophenylamino)isoquinoline-4-carbonitriles as inhibitors of myosin light chain kinase and epidermal growth factor receptor.

Rode HB, Sos ML, Grütter C, Heynck S, Simard JR, Rauh D. Rode HB, et al. Among authors: rauh d. Bioorg Med Chem. 2011 Jan 1;19(1):429-39. doi: 10.1016/j.bmc.2010.11.007. Epub 2010 Nov 10. Bioorg Med Chem. 2011. PMID: 21130659

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