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RNA stores tau reversibly in complex coacervates.
Zhang X, Lin Y, Eschmann NA, Zhou H, Rauch JN, Hernandez I, Guzman E, Kosik KS, Han S. Zhang X, et al. Among authors: rauch jn. PLoS Biol. 2017 Jul 6;15(7):e2002183. doi: 10.1371/journal.pbio.2002183. eCollection 2017 Jul. PLoS Biol. 2017. PMID: 28683104 Free PMC article.
Cofactors are essential constituents of stable and seeding-active tau fibrils.
Fichou Y, Lin Y, Rauch JN, Vigers M, Zeng Z, Srivastava M, Keller TJ, Freed JH, Kosik KS, Han S. Fichou Y, et al. Among authors: rauch jn. Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13234-13239. doi: 10.1073/pnas.1810058115. Epub 2018 Dec 11. Proc Natl Acad Sci U S A. 2018. PMID: 30538196 Free PMC article.
A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy.
Hernandez I, Luna G, Rauch JN, Reis SA, Giroux M, Karch CM, Boctor D, Sibih YE, Storm NJ, Diaz A, Kaushik S, Zekanowski C, Kang AA, Hinman CR, Cerovac V, Guzman E, Zhou H, Haggarty SJ, Goate AM, Fisher SK, Cuervo AM, Kosik KS. Hernandez I, et al. Among authors: rauch jn. Sci Transl Med. 2019 Mar 27;11(485):eaat3005. doi: 10.1126/scitranslmed.aat3005. Sci Transl Med. 2019. PMID: 30918111 Free PMC article.
LRP1 is a master regulator of tau uptake and spread.
Rauch JN, Luna G, Guzman E, Audouard M, Challis C, Sibih YE, Leshuk C, Hernandez I, Wegmann S, Hyman BT, Gradinaru V, Kampmann M, Kosik KS. Rauch JN, et al. Nature. 2020 Apr;580(7803):381-385. doi: 10.1038/s41586-020-2156-5. Epub 2020 Apr 1. Nature. 2020. PMID: 32296178 Free PMC article.
Comparison of Severe Acute Respiratory Syndrome Coronavirus 2 Screening Using Reverse Transcriptase-Quantitative Polymerase Chain Reaction or CRISPR-Based Assays in Asymptomatic College Students.
Rauch JN, Valois E, Ponce-Rojas JC, Aralis Z, Lach RS, Zappa F, Audouard M, Solley SC, Vaidya C, Costello M, Smith H, Javanbakht A, Malear B, Polito L, Comer S, Arn K, Kosik KS, Acosta-Alvear D, Wilson MZ, Fitzgibbons L, Arias C. Rauch JN, et al. JAMA Netw Open. 2021 Feb 1;4(2):e2037129. doi: 10.1001/jamanetworkopen.2020.37129. JAMA Netw Open. 2021. PMID: 33570576 Free PMC article.
39 results