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A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria.
Phillips MA, Lotharius J, Marsh K, White J, Dayan A, White KL, Njoroge JW, El Mazouni F, Lao Y, Kokkonda S, Tomchick DR, Deng X, Laird T, Bhatia SN, March S, Ng CL, Fidock DA, Wittlin S, Lafuente-Monasterio M, Benito FJ, Alonso LM, Martinez MS, Jimenez-Diaz MB, Bazaga SF, Angulo-Barturen I, Haselden JN, Louttit J, Cui Y, Sridhar A, Zeeman AM, Kocken C, Sauerwein R, Dechering K, Avery VM, Duffy S, Delves M, Sinden R, Ruecker A, Wickham KS, Rochford R, Gahagen J, Iyer L, Riccio E, Mirsalis J, Bathhurst I, Rueckle T, Ding X, Campo B, Leroy D, Rogers MJ, Rathod PK, Burrows JN, Charman SA. Phillips MA, et al. Among authors: rathod pk. Sci Transl Med. 2015 Jul 15;7(296):296ra111. doi: 10.1126/scitranslmed.aaa6645. Sci Transl Med. 2015. PMID: 26180101 Free PMC article.
Prized malaria drug target nailed.
Rathod PK, Phillips MA. Rathod PK, et al. Nat Struct Biol. 2003 May;10(5):316-8. doi: 10.1038/nsb0503-316. Nat Struct Biol. 2003. PMID: 12714998 No abstract available.
Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum.
Eastman RT, White J, Hucke O, Bauer K, Yokoyama K, Nallan L, Chakrabarti D, Verlinde CL, Gelb MH, Rathod PK, Van Voorhis WC. Eastman RT, et al. Among authors: rathod pk. J Biol Chem. 2005 Apr 8;280(14):13554-9. doi: 10.1074/jbc.M413556200. Epub 2005 Jan 20. J Biol Chem. 2005. PMID: 15661734 Free article.
122 results