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MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function.
Sugiura A, Andrejeva G, Voss K, Heintzman DR, Xu X, Madden MZ, Ye X, Beier KL, Chowdhury NU, Wolf MM, Young AC, Greenwood DL, Sewell AE, Shahi SK, Freedman SN, Cameron AM, Foerch P, Bourne T, Garcia-Canaveras JC, Karijolich J, Newcomb DC, Mangalam AK, Rabinowitz JD, Rathmell JC. Sugiura A, et al. Among authors: rathmell jc. Immunity. 2022 Jan 11;55(1):65-81.e9. doi: 10.1016/j.immuni.2021.10.011. Epub 2021 Nov 11. Immunity. 2022. PMID: 34767747 Free PMC article.
AIF Is "Always In Fashion" for T Cells.
Johnson MO, Rathmell JC. Johnson MO, et al. Among authors: rathmell jc. Immunity. 2016 Jan 19;44(1):11-13. doi: 10.1016/j.immuni.2015.12.015. Immunity. 2016. PMID: 26789917 Free PMC article.
Biochemical Underpinnings of Immune Cell Metabolic Phenotypes.
Olenchock BA, Rathmell JC, Vander Heiden MG. Olenchock BA, et al. Among authors: rathmell jc. Immunity. 2017 May 16;46(5):703-713. doi: 10.1016/j.immuni.2017.04.013. Immunity. 2017. PMID: 28514672 Free PMC article. Review.
MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation.
Lee KM, Giltnane JM, Balko JM, Schwarz LJ, Guerrero-Zotano AL, Hutchinson KE, Nixon MJ, Estrada MV, Sánchez V, Sanders ME, Lee T, Gómez H, Lluch A, Pérez-Fidalgo JA, Wolf MM, Andrejeva G, Rathmell JC, Fesik SW, Arteaga CL. Lee KM, et al. Among authors: rathmell jc. Cell Metab. 2017 Oct 3;26(4):633-647.e7. doi: 10.1016/j.cmet.2017.09.009. Cell Metab. 2017. PMID: 28978427 Free PMC article.
Metabolic Barriers to T Cell Function in Tumors.
Sugiura A, Rathmell JC. Sugiura A, et al. Among authors: rathmell jc. J Immunol. 2018 Jan 15;200(2):400-407. doi: 10.4049/jimmunol.1701041. J Immunol. 2018. PMID: 29311381 Free PMC article. Review.
Mutant KRAS Exosomes Alter the Metabolic State of Recipient Colonic Epithelial Cells.
Zhang Q, Jeppesen DK, Higginbotham JN, Demory Beckler M, Poulin EJ, Walsh AJ, Skala MC, McKinley ET, Manning HC, Hight MR, Schulte ML, Watt KR, Ayers GD, Wolf MM, Andrejeva G, Rathmell JC, Franklin JL, Coffey RJ. Zhang Q, et al. Among authors: rathmell jc. Cell Mol Gastroenterol Hepatol. 2018 Jan 31;5(4):627-629.e6. doi: 10.1016/j.jcmgh.2018.01.013. eCollection 2018. Cell Mol Gastroenterol Hepatol. 2018. PMID: 29930982 Free PMC article. No abstract available.
Targeting PIM Kinase with PD1 Inhibition Improves Immunotherapeutic Antitumor T-cell Response.
Chatterjee S, Chakraborty P, Daenthanasanmak A, Iamsawat S, Andrejeva G, Luevano LA, Wolf M, Baliga U, Krieg C, Beeson CC, Mehrotra M, Hill EG, Rathmell JC, Yu XZ, Kraft AS, Mehrotra S. Chatterjee S, et al. Among authors: rathmell jc. Clin Cancer Res. 2019 Feb 1;25(3):1036-1049. doi: 10.1158/1078-0432.CCR-18-0706. Epub 2018 Oct 16. Clin Cancer Res. 2019. PMID: 30327305 Free PMC article.
Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism.
Johnson MO, Wolf MM, Madden MZ, Andrejeva G, Sugiura A, Contreras DC, Maseda D, Liberti MV, Paz K, Kishton RJ, Johnson ME, de Cubas AA, Wu P, Li G, Zhang Y, Newcomb DC, Wells AD, Restifo NP, Rathmell WK, Locasale JW, Davila ML, Blazar BR, Rathmell JC. Johnson MO, et al. Among authors: rathmell jc, rathmell wk. Cell. 2018 Dec 13;175(7):1780-1795.e19. doi: 10.1016/j.cell.2018.10.001. Epub 2018 Nov 1. Cell. 2018. PMID: 30392958 Free PMC article.
223 results