Rathmell JC - Search Results

1

GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy.

Ancey PB, Contat C, Boivin G, Sabatino S, Pascual J, Zangger N, Perentes JY, Peters S, Abel ED, Kirsch DG, Rathmell JC, Vozenin MC, Meylan E. Ancey PB, et al. Among authors: rathmell jc. Cancer Res. 2021 May 1;81(9):2345-2357. doi: 10.1158/0008-5472.CAN-20-2870. Epub 2021 Mar 22. Cancer Res. 2021. PMID: 33753374 Free PMC article.

2

IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival.

Wofford JA, Wieman HL, Jacobs SR, Zhao Y, Rathmell JC. Wofford JA, et al. Among authors: rathmell jc. Blood. 2008 Feb 15;111(4):2101-11. doi: 10.1182/blood-2007-06-096297. Epub 2007 Nov 27. Blood. 2008. PMID: 18042802 Free PMC article.

3

Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl.

Mason EF, Zhao Y, Goraksha-Hicks P, Coloff JL, Gannon H, Jones SN, Rathmell JC. Mason EF, et al. Among authors: rathmell jc. Cancer Res. 2010 Oct 15;70(20):8066-76. doi: 10.1158/0008-5472.CAN-10-0608. Epub 2010 Sep 28. Cancer Res. 2010. PMID: 20876800 Free PMC article.

4

Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition.

Coloff JL, Macintyre AN, Nichols AG, Liu T, Gallo CA, Plas DR, Rathmell JC. Coloff JL, et al. Among authors: rathmell jc. Cancer Res. 2011 Aug 1;71(15):5204-13. doi: 10.1158/0008-5472.CAN-10-4531. Epub 2011 Jun 13. Cancer Res. 2011. PMID: 21670080 Free PMC article.

5

Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells.

Caro-Maldonado A, Wang R, Nichols AG, Kuraoka M, Milasta S, Sun LD, Gavin AL, Abel ED, Kelsoe G, Green DR, Rathmell JC. Caro-Maldonado A, et al. Among authors: rathmell jc. J Immunol. 2014 Apr 15;192(8):3626-36. doi: 10.4049/jimmunol.1302062. Epub 2014 Mar 10. J Immunol. 2014. PMID: 24616478 Free PMC article.

6

The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function.

Macintyre AN, Gerriets VA, Nichols AG, Michalek RD, Rudolph MC, Deoliveira D, Anderson SM, Abel ED, Chen BJ, Hale LP, Rathmell JC. Macintyre AN, et al. Among authors: rathmell jc. Cell Metab. 2014 Jul 1;20(1):61-72. doi: 10.1016/j.cmet.2014.05.004. Epub 2014 Jun 12. Cell Metab. 2014. PMID: 24930970 Free PMC article.

7

Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.

Liu T, Kishton RJ, Macintyre AN, Gerriets VA, Xiang H, Liu X, Abel ED, Rizzieri D, Locasale JW, Rathmell JC. Liu T, et al. Among authors: rathmell jc. Cell Death Dis. 2014 Oct 16;5(10):e1470. doi: 10.1038/cddis.2014.431. Cell Death Dis. 2014. PMID: 25321477 Free PMC article.

8

HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism.

Zhang M, Qiu Q, Li Z, Sachdeva M, Min H, Cardona DM, DeLaney TF, Han T, Ma Y, Luo L, Ilkayeva OR, Lui K, Nichols AG, Newgard CB, Kastan MB, Rathmell JC, Dewhirst MW, Kirsch DG. Zhang M, et al. Among authors: rathmell jc. Radiat Res. 2015 Jun;183(6):594-609. doi: 10.1667/RR14016.1. Epub 2015 May 14. Radiat Res. 2015. PMID: 25973951 Free PMC article.

9

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.

Ho PC, Bihuniak JD, Macintyre AN, Staron M, Liu X, Amezquita R, Tsui YC, Cui G, Micevic G, Perales JC, Kleinstein SH, Abel ED, Insogna KL, Feske S, Locasale JW, Bosenberg MW, Rathmell JC, Kaech SM. Ho PC, et al. Among authors: rathmell jc. Cell. 2015 Sep 10;162(6):1217-28. doi: 10.1016/j.cell.2015.08.012. Epub 2015 Aug 27. Cell. 2015. PMID: 26321681 Free PMC article.

10

AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.

Kishton RJ, Barnes CE, Nichols AG, Cohen S, Gerriets VA, Siska PJ, Macintyre AN, Goraksha-Hicks P, de Cubas AA, Liu T, Warmoes MO, Abel ED, Yeoh AE, Gershon TR, Rathmell WK, Richards KL, Locasale JW, Rathmell JC. Kishton RJ, et al. Among authors: rathmell jc, rathmell wk. Cell Metab. 2016 Apr 12;23(4):649-62. doi: 10.1016/j.cmet.2016.03.008. Cell Metab. 2016. PMID: 27076078 Free PMC article.

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