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Factor inhibiting HIF can catalyze two asparaginyl hydroxylations in VNVN motifs of ankyrin fold proteins.
Leissing TM, Hardy AP, Chan H, Wang Y, Tumber A, Chowdhury R, Feng T, Coleman ML, Cockman ME, Kramer HB, Berridge G, Fischer R, Kessler BM, Ratcliffe PJ, Lu X, Schofield CJ. Leissing TM, et al. Among authors: ratcliffe pj. J Biol Chem. 2022 Jun;298(6):102020. doi: 10.1016/j.jbc.2022.102020. Epub 2022 May 7. J Biol Chem. 2022. PMID: 35537551 Free PMC article.
The use of dioxygen by HIF prolyl hydroxylase (PHD1).
McNeill LA, Hewitson KS, Gleadle JM, Horsfall LE, Oldham NJ, Maxwell PH, Pugh CW, Ratcliffe PJ, Schofield CJ. McNeill LA, et al. Among authors: ratcliffe pj. Bioorg Med Chem Lett. 2002 Jun 17;12(12):1547-50. doi: 10.1016/s0960-894x(02)00219-6. Bioorg Med Chem Lett. 2002. PMID: 12039559
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.
Hewitson KS, McNeill LA, Riordan MV, Tian YM, Bullock AN, Welford RW, Elkins JM, Oldham NJ, Bhattacharya S, Gleadle JM, Ratcliffe PJ, Pugh CW, Schofield CJ. Hewitson KS, et al. Among authors: ratcliffe pj. J Biol Chem. 2002 Jul 19;277(29):26351-5. doi: 10.1074/jbc.C200273200. Epub 2002 May 31. J Biol Chem. 2002. PMID: 12042299 Free article.
Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
Schlemminger I, Mole DR, McNeill LA, Dhanda A, Hewitson KS, Tian YM, Ratcliffe PJ, Pugh CW, Schofield CJ. Schlemminger I, et al. Among authors: ratcliffe pj. Bioorg Med Chem Lett. 2003 Apr 17;13(8):1451-4. doi: 10.1016/s0960-894x(03)00149-5. Bioorg Med Chem Lett. 2003. PMID: 12668010
327 results