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Cerebral organoids derived from patients with Alzheimer's disease with PSEN1/2 mutations have defective tissue patterning and altered development.
Vanova T, Sedmik J, Raska J, Amruz Cerna K, Taus P, Pospisilova V, Nezvedova M, Fedorova V, Kadakova S, Klimova H, Capandova M, Orviska P, Fojtik P, Bartova S, Plevova K, Spacil Z, Hribkova H, Bohaciakova D. Vanova T, et al. Among authors: raska j. Cell Rep. 2023 Nov 28;42(11):113310. doi: 10.1016/j.celrep.2023.113310. Epub 2023 Oct 20. Cell Rep. 2023. PMID: 37864790 Free article.
Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer's Disease drug candidate.
Nemergut M, Marques SM, Uhrik L, Vanova T, Nezvedova M, Gadara DC, Jha D, Tulis J, Novakova V, Planas-Iglesias J, Kunka A, Legrand A, Hribkova H, Pospisilova V, Sedmik J, Raska J, Prokop Z, Damborsky J, Bohaciakova D, Spacil Z, Hernychova L, Bednar D, Marek M. Nemergut M, et al. Among authors: raska j. Mol Neurodegener. 2023 Jun 6;18(1):38. doi: 10.1186/s13024-023-00620-9. Mol Neurodegener. 2023. PMID: 37280636 Free PMC article.
Ligase 3-mediated end-joining maintains genome stability of human embryonic stem cells.
Kohutova A, Raška J, Kruta M, Seneklova M, Barta T, Fojtik P, Jurakova T, Walter CA, Hampl A, Dvorak P, Rotrekl V. Kohutova A, et al. Among authors: raska j. FASEB J. 2019 Jun;33(6):6778-6788. doi: 10.1096/fj.201801877RR. Epub 2019 Feb 26. FASEB J. 2019. PMID: 30807703
DSBs in hESCs are also repaired via homologous recombination (HR); however, DSB overload, together with massive end protection by 53BP1, triggers competition between error-free HR and mutagenic nonhomologous EJ.-Kohutova, A., Raska, J., Kruta, M., Seneklova, M., Bar …
DSBs in hESCs are also repaired via homologous recombination (HR); however, DSB overload, together with massive end protection by 53BP1, tri …
30 results