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Efficacy, immunogenicity, and safety of a parenteral vaccine against Helicobacter pylori in healthy volunteers challenged with a Cag-positive strain: a randomised, placebo-controlled phase 1/2 study.
Malfertheiner P, Selgrad M, Wex T, Romi B, Borgogni E, Spensieri F, Zedda L, Ruggiero P, Pancotto L, Censini S, Palla E, Kanesa-Thasan N, Scharschmidt B, Rappuoli R, Graham DY, Schiavetti F, Del Giudice G. Malfertheiner P, et al. Among authors: rappuoli r. Lancet Gastroenterol Hepatol. 2018 Oct;3(10):698-707. doi: 10.1016/S2468-1253(18)30125-0. Epub 2018 Jul 2. Lancet Gastroenterol Hepatol. 2018. PMID: 30042064 Clinical Trial.
Analysis of expression of CagA and VacA virulence factors in 43 strains of Helicobacter pylori reveals that clinical isolates can be divided into two major types and that CagA is not necessary for expression of the vacuolating cytotoxin.
Xiang Z, Censini S, Bayeli PF, Telford JL, Figura N, Rappuoli R, Covacci A. Xiang Z, et al. Among authors: rappuoli r. Infect Immun. 1995 Jan;63(1):94-8. doi: 10.1128/iai.63.1.94-98.1995. Infect Immun. 1995. PMID: 7806390 Free PMC article.
Detoxification of the Helicobacter pylori cytotoxin.
Manetti R, Massari P, Marchetti M, Magagnoli C, Nuti S, Lupetti P, Ghiara P, Rappuoli R, Telford JL. Manetti R, et al. Among authors: rappuoli r. Infect Immun. 1997 Nov;65(11):4615-9. doi: 10.1128/iai.65.11.4615-4619.1997. Infect Immun. 1997. PMID: 9353041 Free PMC article.
Therapeutic intragastric vaccination against Helicobacter pylori in mice eradicates an otherwise chronic infection and confers protection against reinfection.
Ghiara P, Rossi M, Marchetti M, Di Tommaso A, Vindigni C, Ciampolini F, Covacci A, Telford JL, De Magistris MT, Pizza M, Rappuoli R, Del Giudice G. Ghiara P, et al. Among authors: rappuoli r. Infect Immun. 1997 Dec;65(12):4996-5002. doi: 10.1128/iai.65.12.4996-5002.1997. Infect Immun. 1997. PMID: 9393788 Free PMC article.
Protection against Helicobacter pylori infection in mice by intragastric vaccination with H. pylori antigens is achieved using a non-toxic mutant of E. coli heat-labile enterotoxin (LT) as adjuvant.
Marchetti M, Rossi M, Giannelli V, Giuliani MM, Pizza M, Censini S, Covacci A, Massari P, Pagliaccia C, Manetti R, Telford JL, Douce G, Dougan G, Rappuoli R, Ghiara P. Marchetti M, et al. Among authors: rappuoli r. Vaccine. 1998 Jan;16(1):33-7. doi: 10.1016/s0264-410x(97)00153-9. Vaccine. 1998. PMID: 9607006
804 results