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Identification of a Thyroid Hormone Derivative as a Pleiotropic Agent for the Treatment of Alzheimer's Disease.
Runfola M, Perni M, Yang X, Marchese M, Bacci A, Mero S, Santorelli FM, Polini B, Chiellini G, Giuliani D, Vilella A, Bodria M, Daini E, Vandini E, Rudge S, Gul S, Wakelam MOJ, Vendruscolo M, Rapposelli S. Runfola M, et al. Among authors: rapposelli s. Pharmaceuticals (Basel). 2021 Dec 19;14(12):1330. doi: 10.3390/ph14121330. Pharmaceuticals (Basel). 2021. PMID: 34959730 Free PMC article.
Hit-to-Lead Optimization of Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists with a Diphenylmethane-Scaffold: Design, Synthesis, and Biological Study.
Chiellini G, Nesi G, Sestito S, Chiarugi S, Runfola M, Espinoza S, Sabatini M, Bellusci L, Laurino A, Cichero E, Gainetdinov RR, Fossa P, Raimondi L, Zucchi R, Rapposelli S. Chiellini G, et al. Among authors: rapposelli s. J Med Chem. 2016 Nov 10;59(21):9825-9836. doi: 10.1021/acs.jmedchem.6b01092. Epub 2016 Oct 21. J Med Chem. 2016. PMID: 27731647
New Insights into the Potential Roles of 3-Iodothyronamine (T1AM) and Newly Developed Thyronamine-Like TAAR1 Agonists in Neuroprotection.
Bellusci L, Laurino A, Sabatini M, Sestito S, Lenzi P, Raimondi L, Rapposelli S, Biagioni F, Fornai F, Salvetti A, Rossi L, Zucchi R, Chiellini G. Bellusci L, et al. Among authors: rapposelli s. Front Pharmacol. 2017 Dec 12;8:905. doi: 10.3389/fphar.2017.00905. eCollection 2017. Front Pharmacol. 2017. PMID: 29311919 Free PMC article.
Memantine prodrug as a new agent for Alzheimer's Disease.
Sestito S, Daniele S, Pietrobono D, Citi V, Bellusci L, Chiellini G, Calderone V, Martini C, Rapposelli S. Sestito S, et al. Among authors: rapposelli s. Sci Rep. 2019 Mar 15;9(1):4612. doi: 10.1038/s41598-019-40925-8. Sci Rep. 2019. PMID: 30874573 Free PMC article.
Multi-targeted ChEI-copper chelating molecules as neuroprotective agents.
Sestito S, Wang S, Chen Q, Lu J, Bertini S, Pomelli C, Chiellini G, He X, Pi R, Rapposelli S. Sestito S, et al. Among authors: rapposelli s. Eur J Med Chem. 2019 Jul 15;174:216-225. doi: 10.1016/j.ejmech.2019.04.060. Epub 2019 Apr 23. Eur J Med Chem. 2019. PMID: 31042617
119 results