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Molecular Chaperones and Thyroid Cancer.
Paladino L, Vitale AM, Santonocito R, Pitruzzella A, Cipolla C, Graceffa G, Bucchieri F, Conway de Macario E, Macario AJL, Rappa F. Paladino L, et al. Among authors: rappa f. Int J Mol Sci. 2021 Apr 18;22(8):4196. doi: 10.3390/ijms22084196. Int J Mol Sci. 2021. PMID: 33919591 Free PMC article. Review.
Changes in immunohistochemical levels and subcellular localization after therapy and correlation and colocalization with CD68 suggest a pathogenetic role of Hsp60 in ulcerative colitis.
Tomasello G, Rodolico V, Zerilli M, Martorana A, Bucchieri F, Pitruzzella A, Marino Gammazza A, David S, Rappa F, Zummo G, Damiani P, Accomando S, Rizzo M, de Macario EC, Macario AJ, Cappello F. Tomasello G, et al. Among authors: rappa f. Appl Immunohistochem Mol Morphol. 2011 Dec;19(6):552-61. doi: 10.1097/PAI.0b013e3182118e5f. Appl Immunohistochem Mol Morphol. 2011. PMID: 21441812 Clinical Trial.
Heat-shock protein 60 kDa and atherogenic dyslipidemia in patients with untreated mild periodontitis: a pilot study.
Rizzo M, Cappello F, Marfil R, Nibali L, Marino Gammazza A, Rappa F, Bonaventura G, Galindo-Moreno P, O'Valle F, Zummo G, Conway de Macario E, Macario AJ, Mesa F. Rizzo M, et al. Among authors: rappa f. Cell Stress Chaperones. 2012 May;17(3):399-407. doi: 10.1007/s12192-011-0315-1. Epub 2012 Jan 4. Cell Stress Chaperones. 2012. PMID: 22215516 Free PMC article.
Gut microbiota imbalance and chaperoning system malfunction are central to ulcerative colitis pathogenesis and can be counteracted with specifically designed probiotics: a working hypothesis.
Bellavia M, Tomasello G, Romeo M, Damiani P, Lo Monte AI, Lozio L, Campanella C, Marino Gammazza A, Rappa F, Zummo G, Cocchi M, Conway de Macario E, Macario AJ, Cappello F. Bellavia M, et al. Among authors: rappa f. Med Microbiol Immunol. 2013 Dec;202(6):393-406. doi: 10.1007/s00430-013-0305-2. Epub 2013 Jul 18. Med Microbiol Immunol. 2013. PMID: 23864544 Review.
Elevated blood Hsp60, its structural similarities and cross-reactivity with thyroid molecules, and its presence on the plasma membrane of oncocytes point to the chaperonin as an immunopathogenic factor in Hashimoto's thyroiditis.
Marino Gammazza A, Rizzo M, Citarrella R, Rappa F, Campanella C, Bucchieri F, Patti A, Nikolic D, Cabibi D, Amico G, Conaldi PG, San Biagio PL, Montalto G, Farina F, Zummo G, Conway de Macario E, Macario AJ, Cappello F. Marino Gammazza A, et al. Among authors: rappa f. Cell Stress Chaperones. 2014 May;19(3):343-53. doi: 10.1007/s12192-013-0460-9. Epub 2013 Sep 22. Cell Stress Chaperones. 2014. PMID: 24057177 Free PMC article.
Heat shock protein 60 levels in tissue and circulating exosomes in human large bowel cancer before and after ablative surgery.
Campanella C, Rappa F, Sciumè C, Marino Gammazza A, Barone R, Bucchieri F, David S, Curcurù G, Caruso Bavisotto C, Pitruzzella A, Geraci G, Modica G, Farina F, Zummo G, Fais S, Conway de Macario E, Macario AJ, Cappello F. Campanella C, et al. Among authors: rappa f. Cancer. 2015 Sep 15;121(18):3230-9. doi: 10.1002/cncr.29499. Epub 2015 Jun 8. Cancer. 2015. PMID: 26060090 Free article.
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