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Molecular engineering of a cryptic epitope in Spike RBD improves manufacturability and neutralizing breadth against SARS-CoV-2 variants.
Rodriguez-Aponte SA, Dalvie NC, Wong TY, Johnston RS, Naranjo CA, Bajoria S, Kumru OS, Kaur K, Russ BP, Lee KS, Cyphert HA, Barbier M, Rao HD, Rajurkar MP, Lothe RR, Shaligram US, Batwal S, Chandrasekaran R, Nagar G, Kleanthous H, Biswas S, Bevere JR, Joshi SB, Volkin DB, Damron FH, Love JC. Rodriguez-Aponte SA, et al. Among authors: rao hd. Vaccine. 2023 Jan 27;41(5):1108-1118. doi: 10.1016/j.vaccine.2022.12.062. Epub 2022 Dec 29. Vaccine. 2023. PMID: 36610932 Free PMC article.
Scalable, methanol-free manufacturing of the SARS-CoV-2 receptor binding domain in engineered Komagataella phaffii.
Dalvie NC, Biedermann AM, Rodriguez-Aponte SA, Naranjo CA, Rao HD, Rajurkar MP, Lothe RR, Shaligram US, Johnston RS, Crowell LE, Castelino S, Tracey MK, Whittaker CA, Love JC. Dalvie NC, et al. Among authors: rao hd. bioRxiv [Preprint]. 2021 Apr 15:2021.04.15.440035. doi: 10.1101/2021.04.15.440035. bioRxiv. 2021. PMID: 33880471 Free PMC article. Updated. Preprint.
Scalable, methanol-free manufacturing of the SARS-CoV-2 receptor-binding domain in engineered Komagataella phaffii.
Dalvie NC, Biedermann AM, Rodriguez-Aponte SA, Naranjo CA, Rao HD, Rajurkar MP, Lothe RR, Shaligram US, Johnston RS, Crowell LE, Castelino S, Tracey MK, Whittaker CA, Love JC. Dalvie NC, et al. Among authors: rao hd. Biotechnol Bioeng. 2022 Feb;119(2):657-662. doi: 10.1002/bit.27979. Epub 2021 Nov 15. Biotechnol Bioeng. 2022. PMID: 34780057 Free PMC article.
SARS-CoV-2 receptor binding domain displayed on HBsAg virus-like particles elicits protective immunity in macaques.
Dalvie NC, Tostanoski LH, Rodriguez-Aponte SA, Kaur K, Bajoria S, Kumru OS, Martinot AJ, Chandrashekar A, McMahan K, Mercado NB, Yu J, Chang A, Giffin VM, Nampanya F, Patel S, Bowman L, Naranjo CA, Yun D, Flinchbaugh Z, Pessaint L, Brown R, Velasco J, Teow E, Cook A, Andersen H, Lewis MG, Camp DL, Silverman JM, Nagar GS, Rao HD, Lothe RR, Chandrasekharan R, Rajurkar MP, Shaligram US, Kleanthous H, Joshi SB, Volkin DB, Biswas S, Love JC, Barouch DH. Dalvie NC, et al. Among authors: rao hd. Sci Adv. 2022 Mar 18;8(11):eabl6015. doi: 10.1126/sciadv.abl6015. Epub 2022 Mar 16. Sci Adv. 2022. PMID: 35294244 Free PMC article.
Analytical and Preformulation Characterization Studies of Human Papillomavirus Virus-Like Particles to Enable Quadrivalent Multi-Dose Vaccine Formulation Development.
Jerajani K, Wan Y, Hickey JM, Kumru OS, Sharma N, Pullagurla SR, Ogun O, Mapari S, Whitaker N, Brendle S, Christensen ND, Batwal S, Mahedvi M, Rao H, Dogar V, Chandrasekharan R, Shaligram U, Joshi SB, Volkin DB. Jerajani K, et al. J Pharm Sci. 2022 Nov;111(11):2983-2997. doi: 10.1016/j.xphs.2022.07.019. Epub 2022 Jul 30. J Pharm Sci. 2022. PMID: 35914546 Free article.
RBD-VLP Vaccines Adjuvanted with Alum or SWE Protect K18-hACE2 Mice against SARS-CoV-2 VOC Challenge.
Wong TY, Russ BP, Lee KS, Miller OA, Kang J, Cooper M, Winters MT, Rodriguez-Aponte SA, Dalvie NC, Johnston RS, Rader NA, Wong ZY, Cyphert HA, Martinez I, Shaligram U, Batwal S, Lothe R, Chandrasekaran R, Nagar G, Rajurkar M, Rao H, Bevere JR, Barbier M, Love JC, Damron FH. Wong TY, et al. mSphere. 2022 Aug 31;7(4):e0024322. doi: 10.1128/msphere.00243-22. Epub 2022 Aug 15. mSphere. 2022. PMID: 35968964 Free PMC article.
Multi-Dose Formulation Development for a Quadrivalent Human Papillomavirus Virus-Like Particle-Based Vaccine: Part I - Screening of Preservative Combinations.
Jerajani K, Wan Y, Kumru OS, Pullagurla SR, Kumar P, Sharma N, Ogun O, Mapari S, Brendle S, Christensen ND, Batwal S, Mahedvi M, Rao H, Dogar V, Chandrasekharan R, Shaligram U, Joshi SB, Volkin DB. Jerajani K, et al. J Pharm Sci. 2023 Feb;112(2):446-457. doi: 10.1016/j.xphs.2022.09.001. Epub 2022 Sep 9. J Pharm Sci. 2023. PMID: 36096284 Free article.
Multi-dose Formulation Development for a Quadrivalent Human Papillomavirus Virus-Like Particle-Based Vaccine: Part II- Real-time and Accelerated Stability Studies.
Sharma N, Jerajani K, Wan Y, Kumru OS, Pullagurla SR, Ogun O, Mapari S, Brendle S, Christensen ND, Batwal S, Mahedvi M, Rao H, Dogar V, Chandrasekharan R, Shaligram U, Volkin DB, Joshi SB. Sharma N, et al. J Pharm Sci. 2023 Feb;112(2):458-470. doi: 10.1016/j.xphs.2022.11.021. Epub 2022 Dec 1. J Pharm Sci. 2023. PMID: 36462710 Free article.
18 results