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Mitochondrial uncoupling protein-2 reprograms metabolism to induce oxidative stress and myofibroblast senescence in age-associated lung fibrosis.
Rangarajan S, Locy ML, Chanda D, Kurundkar A, Kurundkar D, Larson-Casey JL, Londono P, Bagchi RA, Deskin B, Elajaili H, Nozik ES, Deshane JS, Zmijewski JW, Eickelberg O, Thannickal VJ. Rangarajan S, et al. Aging Cell. 2022 Sep;21(9):e13674. doi: 10.1111/acel.13674. Epub 2022 Aug 7. Aging Cell. 2022. PMID: 35934931 Free PMC article.
Novel Mechanisms for the Antifibrotic Action of Nintedanib.
Rangarajan S, Kurundkar A, Kurundkar D, Bernard K, Sanders YY, Ding Q, Antony VB, Zhang J, Zmijewski J, Thannickal VJ. Rangarajan S, et al. Am J Respir Cell Mol Biol. 2016 Jan;54(1):51-9. doi: 10.1165/rcmb.2014-0445OC. Am J Respir Cell Mol Biol. 2016. PMID: 26072676 Free PMC article.
The matricellular protein CCN1 enhances TGF-β1/SMAD3-dependent profibrotic signaling in fibroblasts and contributes to fibrogenic responses to lung injury.
Kurundkar AR, Kurundkar D, Rangarajan S, Locy ML, Zhou Y, Liu RM, Zmijewski J, Thannickal VJ. Kurundkar AR, et al. Among authors: rangarajan s. FASEB J. 2016 Jun;30(6):2135-50. doi: 10.1096/fj.201500173. Epub 2016 Feb 16. FASEB J. 2016. PMID: 26884454 Free PMC article.
These studies support previously unrecognized, cooperative interaction between the CCN1 matricellular protein and canonical TGF-beta1/SMAD3 signaling that promotes lung fibrosis.-Kurundkar, A. R., Kurundkar, D., Rangarajan, S., Locy, M. L., Zhou, Y., Liu, R.-M., Zmi …
These studies support previously unrecognized, cooperative interaction between the CCN1 matricellular protein and canonical TGF-beta1/SMAD3 …
Distal airway microbiome is associated with immunoregulatory myeloid cell responses in lung transplant recipients.
Sharma NS, Wille KM, Athira S, Zhi D, Hough KP, Diaz-Guzman E, Zhang K, Kumar R, Rangarajan S, Eipers P, Wang Y, Srivastava RK, Rodriguez Dager JV, Athar M, Morrow C, Hoopes CW, Chaplin DD, Thannickal VJ, Deshane JS. Sharma NS, et al. Among authors: rangarajan s. J Heart Lung Transplant. 2017 Jul 15:S1053-2498(17)31898-3. doi: 10.1016/j.healun.2017.07.007. Online ahead of print. J Heart Lung Transplant. 2017. PMID: 28756121 Free PMC article.
Mitochondrial Dysfunction in Pulmonary Fibrosis.
Rangarajan S, Bernard K, Thannickal VJ. Rangarajan S, et al. Ann Am Thorac Soc. 2017 Nov;14(Supplement_5):S383-S388. doi: 10.1513/AnnalsATS.201705-370AW. Ann Am Thorac Soc. 2017. PMID: 29161077 Free PMC article. Review.
524 results