Randolph JT - Search Results

1

Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailability.

Randolph JT, Krueger AC, Donner PL, Pratt JK, Liu D, Motter CE, Rockway TW, Tufano MD, Wagner R, Lim HB, Beyer JM, Mondal R, Panchal NS, Colletti L, Liu Y, Koev G, Kati WM, Hernandez LE, Beno DWA, Longenecker KL, Stewart KD, Dumas EO, Molla A, Maring CJ. Randolph JT, et al. J Med Chem. 2018 Feb 8;61(3):1153-1163. doi: 10.1021/acs.jmedchem.7b01630. Epub 2018 Jan 25. J Med Chem. 2018. PMID: 29342358

2

Nonpeptide luteinizing hormone-releasing hormone antagonists derived from erythromycin A: design, synthesis, and biological activity of cladinose replacement analogues.

Randolph JT, Waid P, Nichols C, Sauer D, Haviv F, Diaz G, Bammert G, Besecke LM, Segreti JA, Mohning KM, Bush EN, Wegner CD, Greer J. Randolph JT, et al. J Med Chem. 2004 Feb 26;47(5):1085-97. doi: 10.1021/jm030418i. J Med Chem. 2004. PMID: 14971889

3

Mutations conferring resistance to a potent hepatitis C virus serine protease inhibitor in vitro.

Lu L, Pilot-Matias TJ, Stewart KD, Randolph JT, Pithawalla R, He W, Huang PP, Klein LL, Mo H, Molla A. Lu L, et al. Among authors: randolph jt. Antimicrob Agents Chemother. 2004 Jun;48(6):2260-6. doi: 10.1128/AAC.48.6.2260-2266.2004. Antimicrob Agents Chemother. 2004. PMID: 15155230 Free PMC article.

4

Peptidomimetic inhibitors of HIV protease.

Randolph JT, DeGoey DA. Randolph JT, et al. Curr Top Med Chem. 2004;4(10):1079-95. doi: 10.2174/1568026043388330. Curr Top Med Chem. 2004. PMID: 15193140 Review.

5

Synthesis, antiviral activity, and pharmacokinetic evaluation of P3 pyridylmethyl analogs of oximinoarylsulfonyl HIV-1 protease inhibitors.

Randolph JT, Huang PP, Flosi WJ, DeGoey D, Klein LL, Yeung CM, Flentge C, Sun M, Zhao C, Dekhtyar T, Mo H, Colletti L, Kati W, Marsh KC, Molla A, Kempf DJ. Randolph JT, et al. Bioorg Med Chem. 2006 Jun 15;14(12):4035-46. doi: 10.1016/j.bmc.2006.02.013. Epub 2006 Feb 28. Bioorg Med Chem. 2006. PMID: 16504523

6

Pharmacokinetic enhancement of the hepatitis C virus protease inhibitors VX-950 and SCH 503034 by co-dosing with ritonavir.

Kempf DJ, Klein C, Chen HJ, Klein LL, Yeung C, Randolph JT, Lau YY, Chovan LE, Guan Z, Hernandez L, Turner TM, Dandliker PJ, Marsh KC. Kempf DJ, et al. Among authors: randolph jt. Antivir Chem Chemother. 2007;18(3):163-7. doi: 10.1177/095632020701800306. Antivir Chem Chemother. 2007. PMID: 17626600 Free article.

7

Longer wavelength fluorescence resonance energy transfer depsipeptide substrates for hepatitis C virus NS3 protease.

Konstantinidis AK, Richardson PL, Kurtz KA, Tripathi R, Chen CM, Huang P, Randolph J, Towne D, Donnelly J, Warrior U, Middleton T, Kati WM. Konstantinidis AK, et al. Anal Biochem. 2007 Sep 15;368(2):156-67. doi: 10.1016/j.ab.2007.06.020. Epub 2007 Jun 17. Anal Biochem. 2007. PMID: 17644059

8

Synthesis, antiviral activity, and conformational studies of a P3 aza-peptide analog of a potent macrocyclic tripeptide HCV protease inhibitor.

Randolph JT, Zhang X, Huang PP, Klein LL, Kurtz KA, Konstantinidis AK, He W, Kati WM, Kempf DJ. Randolph JT, et al. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2745-50. doi: 10.1016/j.bmcl.2008.02.053. Epub 2008 Feb 26. Bioorg Med Chem Lett. 2008. PMID: 18375121

9

2-Pyridyl P1'-substituted symmetry-based human immunodeficiency virus protease inhibitors (A-792611 and A-790742) with potential for convenient dosing and reduced side effects.

Degoey DA, Grampovnik DJ, Flentge CA, Flosi WJ, Chen HJ, Yeung CM, Randolph JT, Klein LL, Dekhtyar T, Colletti L, Marsh KC, Stoll V, Mamo M, Morfitt DC, Nguyen B, Schmidt JM, Swanson SJ, Mo H, Kati WM, Molla A, Kempf DJ. Degoey DA, et al. Among authors: randolph jt. J Med Chem. 2009 Apr 23;52(8):2571-86. doi: 10.1021/jm900044w. J Med Chem. 2009. PMID: 19323562

10

Synthesis and biological characterization of B-ring amino analogues of potent benzothiadiazine hepatitis C virus polymerase inhibitors.

Randolph JT, Flentge CA, Huang PP, Hutchinson DK, Klein LL, Lim HB, Mondal R, Reisch T, Montgomery DA, Jiang WW, Masse SV, Hernandez LE, Henry RF, Liu Y, Koev G, Kati WM, Stewart KD, Beno DW, Molla A, Kempf DJ. Randolph JT, et al. J Med Chem. 2009 May 28;52(10):3174-83. doi: 10.1021/jm801485z. J Med Chem. 2009. PMID: 19402666

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