Rana TM - Search Results

1

Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance.

Nalam MN, Ali A, Reddy GS, Cao H, Anjum SG, Altman MD, Yilmaz NK, Tidor B, Rana TM, Schiffer CA. Nalam MN, et al. Among authors: rana tm. Chem Biol. 2013 Sep 19;20(9):1116-24. doi: 10.1016/j.chembiol.2013.07.014. Epub 2013 Sep 5. Chem Biol. 2013. PMID: 24012370 Free PMC article.

2

Discovery of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryl-oxazolidinone-5-carboxamides as novel P2 ligands.

Ali A, Reddy GS, Cao H, Anjum SG, Nalam MN, Schiffer CA, Rana TM. Ali A, et al. Among authors: rana tm. J Med Chem. 2006 Dec 14;49(25):7342-56. doi: 10.1021/jm060666p. J Med Chem. 2006. PMID: 17149864

3

Design of mutation-resistant HIV protease inhibitors with the substrate envelope hypothesis.

Chellappan S, Kiran Kumar Reddy GS, Ali A, Nalam MN, Anjum SG, Cao H, Kairys V, Fernandes MX, Altman MD, Tidor B, Rana TM, Schiffer CA, Gilson MK. Chellappan S, et al. Among authors: rana tm. Chem Biol Drug Des. 2007 May;69(5):298-313. doi: 10.1111/j.1747-0285.2007.00514.x. Chem Biol Drug Des. 2007. PMID: 17539822

4

Design and synthesis of HIV-1 protease inhibitors incorporating oxazolidinones as P2/P2' ligands in pseudosymmetric dipeptide isosteres.

Reddy GS, Ali A, Nalam MN, Anjum SG, Cao H, Nathans RS, Schiffer CA, Rana TM. Reddy GS, et al. Among authors: rana tm. J Med Chem. 2007 Sep 6;50(18):4316-28. doi: 10.1021/jm070284z. Epub 2007 Aug 16. J Med Chem. 2007. PMID: 17696512 Free PMC article.

5

HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants.

Altman MD, Ali A, Reddy GS, Nalam MN, Anjum SG, Cao H, Chellappan S, Kairys V, Fernandes MX, Gilson MK, Schiffer CA, Rana TM, Tidor B. Altman MD, et al. Among authors: rana tm. J Am Chem Soc. 2008 May 14;130(19):6099-113. doi: 10.1021/ja076558p. Epub 2008 Apr 16. J Am Chem Soc. 2008. PMID: 18412349 Free PMC article.

6

Additivity in the analysis and design of HIV protease inhibitors.

Jorissen RN, Reddy GS, Ali A, Altman MD, Chellappan S, Anjum SG, Tidor B, Schiffer CA, Rana TM, Gilson MK. Jorissen RN, et al. Among authors: rana tm. J Med Chem. 2009 Feb 12;52(3):737-54. doi: 10.1021/jm8009525. J Med Chem. 2009. PMID: 19193159 Free PMC article.

7

Evaluating the substrate-envelope hypothesis: structural analysis of novel HIV-1 protease inhibitors designed to be robust against drug resistance.

Nalam MN, Ali A, Altman MD, Reddy GS, Chellappan S, Kairys V, Ozen A, Cao H, Gilson MK, Tidor B, Rana TM, Schiffer CA. Nalam MN, et al. Among authors: rana tm. J Virol. 2010 May;84(10):5368-78. doi: 10.1128/JVI.02531-09. Epub 2010 Mar 17. J Virol. 2010. PMID: 20237088 Free PMC article.

8

Structure-based design, synthesis, and structure-activity relationship studies of HIV-1 protease inhibitors incorporating phenyloxazolidinones.

Ali A, Reddy GS, Nalam MN, Anjum SG, Cao H, Schiffer CA, Rana TM. Ali A, et al. Among authors: rana tm. J Med Chem. 2010 Nov 11;53(21):7699-708. doi: 10.1021/jm1008743. J Med Chem. 2010. PMID: 20958050 Free PMC article.

9

Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance.

Parai MK, Huggins DJ, Cao H, Nalam MN, Ali A, Schiffer CA, Tidor B, Rana TM. Parai MK, et al. Among authors: rana tm. J Med Chem. 2012 Jul 26;55(14):6328-41. doi: 10.1021/jm300238h. Epub 2012 Jul 13. J Med Chem. 2012. PMID: 22708897 Free PMC article.

10

Testing the substrate-envelope hypothesis with designed pairs of compounds.

Shen Y, Altman MD, Ali A, Nalam MN, Cao H, Rana TM, Schiffer CA, Tidor B. Shen Y, et al. Among authors: rana tm. ACS Chem Biol. 2013 Nov 15;8(11):2433-41. doi: 10.1021/cb400468c. Epub 2013 Sep 26. ACS Chem Biol. 2013. PMID: 23952265 Free PMC article.

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