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Complementary use of ion trap/time-of-flight mass spectrometry in combination with capillary high-pressure liquid chromatography: early characterization of in vivo metabolites of the cathepsin K inhibitor NVP-AAV490 in rat.
Blum W, Buhl T, Altmann E, Kühnöl J, Ramstein P, Aichholz R. Blum W, et al. Among authors: ramstein p. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Apr 25;787(2):255-70. doi: 10.1016/s1570-0232(02)00782-1. J Chromatogr B Analyt Technol Biomed Life Sci. 2003. PMID: 12650749
Micropreparative isolation and NMR structure elucidation of metabolites of the drug candidate 1-isopropyl-4-(4-isopropylphenyl)-6-(prop-2-yn-1-yloxy) quinazolin-2(1H)-one from rat bile and urine.
Blanz J, Délémonté T, Pearson D, Luneau A, Ritzau M, Gertsch W, Ramstein P, Dayer J, Desrayaud S, Braun E, Aichholz R. Blanz J, et al. Among authors: ramstein p. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 May 1;989:1-10. doi: 10.1016/j.jchromb.2015.02.044. Epub 2015 Mar 10. J Chromatogr B Analyt Technol Biomed Life Sci. 2015. PMID: 25797717
Determination of the GABA(B) receptor agonist CGP 44532 (3-amino-2-hydroxypropylmethylphosphinic acid) in rat plasma after pre-column derivatization by micro-high-performance liquid chromatography combined with negative electrospray tandem mass spectrometry.
Blum W, Aichholz R, Ramstein P, Kühnöl J, Froestl W, Desrayaud S. Blum W, et al. Among authors: ramstein p. J Chromatogr B Biomed Sci Appl. 2000 Oct 10;748(2):349-59. doi: 10.1016/s0378-4347(00)00352-2. J Chromatogr B Biomed Sci Appl. 2000. PMID: 11087077
In vivo metabolism of epothilone B in tumor-bearing nude mice: identification of three new epothilone B metabolites by capillary high-pressure liquid chromatography/mass spectrometry/tandem mass spectrometry.
Blum W, Aichholz R, Ramstein P, Kühnöl J, Brüggen J, O'Reilly T, Flörsheimer A. Blum W, et al. Among authors: ramstein p. Rapid Commun Mass Spectrom. 2001;15(1):41-9. doi: 10.1002/1097-0231(20010115)15:1<41::AID-RCM190>3.0.CO;2-W. Rapid Commun Mass Spectrom. 2001. PMID: 11135423