Ramsay RR - Search Results

1

Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease.

Unzeta M, Esteban G, Bolea I, Fogel WA, Ramsay RR, Youdim MB, Tipton KF, Marco-Contelles J. Unzeta M, et al. Among authors: ramsay rr. Front Neurosci. 2016 May 25;10:205. doi: 10.3389/fnins.2016.00205. eCollection 2016. Front Neurosci. 2016. PMID: 27252617 Free PMC article. Review.

2

ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy.

Marco-Contelles J, Unzeta M, Bolea I, Esteban G, Ramsay RR, Romero A, Martínez-Murillo R, Carreiras MC, Ismaili L. Marco-Contelles J, et al. Among authors: ramsay rr. Front Neurosci. 2016 Jun 28;10:294. doi: 10.3389/fnins.2016.00294. eCollection 2016. Front Neurosci. 2016. PMID: 27445665 Free PMC article.

3

Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease.

Esteban G, Allan J, Samadi A, Mattevi A, Unzeta M, Marco-Contelles J, Binda C, Ramsay RR. Esteban G, et al. Among authors: ramsay rr. Biochim Biophys Acta. 2014 Jun;1844(6):1104-10. doi: 10.1016/j.bbapap.2014.03.006. Epub 2014 Mar 16. Biochim Biophys Acta. 2014. PMID: 24642166

4

Assessment of Enzyme Inhibition: A Review with Examples from the Development of Monoamine Oxidase and Cholinesterase Inhibitory Drugs.

Ramsay RR, Tipton KF. Ramsay RR, et al. Molecules. 2017 Jul 15;22(7):1192. doi: 10.3390/molecules22071192. Molecules. 2017. PMID: 28714881 Free PMC article. Review.

5

Synthesis, biological evaluation, and molecular modeling of nitrile-containing compounds: Exploring multiple activities as anti-Alzheimer agents.

Silva D, Mendes E, Summers EJ, Neca A, Jacinto AC, Reis T, Agostinho P, Bolea I, Jimeno ML, Mateus ML, Oliveira-Campos AMF, Unzeta M, Marco-Contelles J, Majekova M, Ramsay RR, Carreiras MC. Silva D, et al. Among authors: ramsay rr. Drug Dev Res. 2020 Apr;81(2):215-231. doi: 10.1002/ddr.21594. Epub 2019 Aug 30. Drug Dev Res. 2020. PMID: 31471933

6

Evidence for a Cyanine Link Between Propargylamine Drugs and Monoamine Oxidase Clarifies the Inactivation Mechanism.

Albreht A, Vovk I, Mavri J, Marco-Contelles J, Ramsay RR. Albreht A, et al. Among authors: ramsay rr. Front Chem. 2018 May 28;6:169. doi: 10.3389/fchem.2018.00169. eCollection 2018. Front Chem. 2018. PMID: 29892597 Free PMC article.

7

Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease.

Benek O, Soukup O, Pasdiorova M, Hroch L, Sepsova V, Jost P, Hrabinova M, Jun D, Kuca K, Zala D, Ramsay RR, Marco-Contelles J, Musilek K. Benek O, et al. Among authors: ramsay rr. ChemMedChem. 2016 Jun 20;11(12):1264-9. doi: 10.1002/cmdc.201500383. Epub 2015 Oct 2. ChemMedChem. 2016. PMID: 26427608

8

Comparative Analysis of the Neurochemical Profile and MAO Inhibition Properties of N-(Furan-2-ylmethyl)-N-methylprop-2-yn-1-amine.

De Deurwaerdère P, Binda C, Corne R, Leone C, Valeri A, Valoti M, Ramsay RR, Fall Y, Marco-Contelles J. De Deurwaerdère P, et al. Among authors: ramsay rr. ACS Chem Neurosci. 2017 May 17;8(5):1026-1035. doi: 10.1021/acschemneuro.6b00377. Epub 2016 Dec 30. ACS Chem Neurosci. 2017. PMID: 27977122

9

Variations in activity and inhibition with pH: the protonated amine is the substrate for monoamine oxidase, but uncharged inhibitors bind better.

Jones TZ, Balsa D, Unzeta M, Ramsay RR. Jones TZ, et al. Among authors: ramsay rr. J Neural Transm (Vienna). 2007;114(6):707-12. doi: 10.1007/s00702-007-0675-y. Epub 2007 Mar 31. J Neural Transm (Vienna). 2007. PMID: 17401535

10

Key Targets for Multi-Target Ligands Designed to Combat Neurodegeneration.

Ramsay RR, Majekova M, Medina M, Valoti M. Ramsay RR, et al. Front Neurosci. 2016 Aug 22;10:375. doi: 10.3389/fnins.2016.00375. eCollection 2016. Front Neurosci. 2016. PMID: 27597816 Free PMC article. Review.

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