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Identification of novel PI3K inhibitors through a scaffold hopping strategy.
Bioorg Med Chem Lett. 2017 Nov 1;27(21):4794-4799. doi: 10.1016/j.bmcl.2017.09.059. Epub 2017 Sep 30.
Bioorg Med Chem Lett. 2017.
PMID: 29017786
Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor.
Martínez González S, Hernández AI, Varela C, Rodríguez-Arístegui S, Lorenzo M, Rodríguez A, Rivero V, Martín JI, Saluste CG, Ramos-Lima F, Cendón E, Cebrián D, Aguirre E, Gomez-Casero E, Albarrán M, Alfonso P, García-Serelde B, Oyarzabal J, Rabal O, Mulero F, Gonzalez-Granda T, Link W, Fominaya J, Barbacid M, Bischoff JR, Pizcueta P, Pastor J.
Martínez González S, et al. Among authors: ramos lima f.
Bioorg Med Chem Lett. 2012 May 15;22(10):3460-6. doi: 10.1016/j.bmcl.2012.03.090. Epub 2012 Mar 29.
Bioorg Med Chem Lett. 2012.
PMID: 22520259
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Rapid identification of ETP-46992, orally bioavailable PI3K inhibitor, selective versus mTOR.
Martínez González S, Hernández AI, Varela C, Lorenzo M, Ramos-Lima F, Cendón E, Cebrián D, Aguirre E, Gomez-Casero E, Albarrán MI, Alfonso P, García-Serelde B, Mateos G, Oyarzabal J, Rabal O, Mulero F, Gonzalez-Granda T, Link W, Fominaya J, Barbacid M, Bischoff JR, Pizcueta P, Blanco-Aparicio C, Pastor J.
Martínez González S, et al. Among authors: ramos lima f.
Bioorg Med Chem Lett. 2012 Aug 15;22(16):5208-14. doi: 10.1016/j.bmcl.2012.06.093. Epub 2012 Jul 4.
Bioorg Med Chem Lett. 2012.
PMID: 22819764
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New trans-platinum drugs with phosphines and amines as carrier ligands induce apoptosis in tumor cells resistant to cisplatin.
Ramos-Lima FJ, Quiroga AG, García-Serrelde B, Blanco F, Carnero A, Navarro-Ranninger C.
Ramos-Lima FJ, et al.
J Med Chem. 2007 May 3;50(9):2194-9. doi: 10.1021/jm061219c. Epub 2007 Apr 4.
J Med Chem. 2007.
PMID: 17407274
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The role of p53 in the cellular toxicity by active trans-platinum complexes containing isopropylamine and hydroxymethylpyridine.
Ramos-Lima FJ, Moneo V, Quiroga AG, Carnero A, Navarro-Ranninger C.
Ramos-Lima FJ, et al.
Eur J Med Chem. 2010 Jan;45(1):134-41. doi: 10.1016/j.ejmech.2009.09.035. Epub 2009 Oct 1.
Eur J Med Chem. 2010.
PMID: 19853978
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Structural characterization, DNA interactions, and cytotoxicity of new transplatin analogues containing one aliphatic and one planar heterocyclic amine ligand.
Ramos-Lima FJ, Vrána O, Quiroga AG, Navarro-Ranninger C, Halámiková A, Rybnícková H, Hejmalová L, Brabec V.
Ramos-Lima FJ, et al.
J Med Chem. 2006 Apr 20;49(8):2640-51. doi: 10.1021/jm0602514.
J Med Chem. 2006.
PMID: 16610807
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Influence of (hydroxymethyl)pyridine and pyridine-carboxylic acids, in trans-position to the isopropylamine and amine ligands, on the cytotoxicity of platinum complexes.
Medina RM, Rodríguez J, Quiroga AG, Ramos-Lima FJ, Moneo V, Carnero A, Navarro-Ranninger C, Macazaga MJ.
Medina RM, et al. Among authors: ramos lima fj.
Chem Biodivers. 2008 Oct;5(10):2090-2100. doi: 10.1002/cbdv.200890190.
Chem Biodivers. 2008.
PMID: 18972499
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Subcutaneous Sarilumab in hospitalised patients with moderate-severe COVID-19 infection compared to the standard of care (SARCOVID): a structured summary of a study protocol for a randomised controlled trial.
Garcia-Vicuña R, Abad-Santos F, González-Alvaro I, Ramos-Lima F, Sanz JS.
Garcia-Vicuña R, et al. Among authors: ramos lima f.
Trials. 2020 Sep 9;21(1):772. doi: 10.1186/s13063-020-04588-5.
Trials. 2020.
PMID: 32907638
Free PMC article.
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