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JM-20 protects against 6-hydroxydopamine-induced neurotoxicity in models of Parkinson's disease: Mitochondrial protection and antioxidant properties.
Fonseca-Fonseca LA, da Silva VDA, Wong-Guerra M, Ramírez-Sánchez J, Yaquis ASP, Ochoa-Rodríguez E, Verdecia-Reyes Y, de Araújo FM, Santana RC, Outeiro TF, Costa SL, Núñez-Figueredo Y. Fonseca-Fonseca LA, et al. Among authors: ramirez sanchez j. Neurotoxicology. 2021 Jan;82:89-98. doi: 10.1016/j.neuro.2020.11.005. Epub 2020 Nov 21. Neurotoxicology. 2021. PMID: 33232743 Free article.
JM-20, a novel benzodiazepine–dihydropyridine hybrid molecule, protects mitochondria and prevents ischemic insult-mediated neural cell death in vitro.
Nuñez-Figueredo Y, Ramírez-Sánchez J, Delgado-Hernández R, Porto-Verdecia M, Ochoa-Rodríguez E, Verdecia-Reyes Y, Marin-Prida J, González-Durruthy M, Uyemura SA, Rodrigues FP, Curti C, Souza DO, Pardo-Andreu GL. Nuñez-Figueredo Y, et al. Eur J Pharmacol. 2014 Mar 5;726:57-65. doi: 10.1016/j.ejphar.2014.01.021. Eur J Pharmacol. 2014. PMID: 24462350 Free article.
A novel multi-target ligand (JM-20) protects mitochondrial integrity, inhibits brain excitatory amino acid release and reduces cerebral ischemia injury in vitro and in vivo.
Nuñez-Figueredo Y, Ramírez-Sánchez J, Hansel G, Simões Pires EN, Merino N, Valdes O, Delgado-Hernández R, Parra AL, Ochoa-Rodríguez E, Verdecia-Reyes Y, Salbego C, Costa SL, Souza DO, Pardo-Andreu GL. Nuñez-Figueredo Y, et al. Neuropharmacology. 2014 Oct;85:517-27. doi: 10.1016/j.neuropharm.2014.06.009. Epub 2014 Jun 19. Neuropharmacology. 2014. PMID: 24953828
Antioxidant effects of JM-20 on rat brain mitochondria and synaptosomes: mitoprotection against Ca²⁺-induced mitochondrial impairment.
Nuñez-Figueredo Y, Pardo-Andreu GL, Ramírez-Sánchez J, Delgado-Hernández R, Ochoa-Rodríguez E, Verdecia-Reyes Y, Naal Z, Muller AP, Portela LV, Souza DO. Nuñez-Figueredo Y, et al. Brain Res Bull. 2014 Oct;109:68-76. doi: 10.1016/j.brainresbull.2014.10.001. Epub 2014 Oct 13. Brain Res Bull. 2014. PMID: 25305343 Free article.
Neuroprotection by JM-20 against oxygen-glucose deprivation in rat hippocampal slices: Involvement of the Akt/GSK-3β pathway.
Ramírez-Sánchez J, Simões Pires EN, Nuñez-Figueredo Y, Pardo-Andreu GL, Fonseca-Fonseca LA, Ruiz-Reyes A, Ochoa-Rodríguez E, Verdecia-Reyes Y, Delgado-Hernández R, Souza DO, Salbego C. Ramírez-Sánchez J, et al. Neurochem Int. 2015 Nov;90:215-23. doi: 10.1016/j.neuint.2015.09.003. Epub 2015 Sep 8. Neurochem Int. 2015. PMID: 26361722
Mitochondrial involvement in memory impairment induced by scopolamine in rats.
Wong-Guerra M, Jiménez-Martin J, Pardo-Andreu GL, Fonseca-Fonseca LA, Souza DO, de Assis AM, Ramirez-Sanchez J, Del Valle RM, Nuñez-Figueredo Y. Wong-Guerra M, et al. Neurol Res. 2017 Jul;39(7):649-659. doi: 10.1080/01616412.2017.1312775. Epub 2017 Apr 11. Neurol Res. 2017. PMID: 28398193
25 results