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APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes.
Blanchard JW, Akay LA, Davila-Velderrain J, von Maydell D, Mathys H, Davidson SM, Effenberger A, Chen CY, Maner-Smith K, Hajjar I, Ortlund EA, Bula M, Agbas E, Ng A, Jiang X, Kahn M, Blanco-Duque C, Lavoie N, Liu L, Reyes R, Lin YT, Ko T, R'Bibo L, Ralvenius WT, Bennett DA, Cam HP, Kellis M, Tsai LH. Blanchard JW, et al. Among authors: ralvenius wt. Nature. 2022 Nov;611(7937):769-779. doi: 10.1038/s41586-022-05439-w. Epub 2022 Nov 16. Nature. 2022. PMID: 36385529 Free PMC article.
A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation.
Ralvenius WT, Mungenast AE, Woolf H, Huston MM, Gillingham TZ, Godin SK, Penney J, Cam HP, Gao F, Fernandez CG, Czako B, Lightfoot Y, Ray WJ, Beckmann A, Goate AM, Marcora E, Romero-Molina C, Ayata P, Schaefer A, Gjoneska E, Tsai LH. Ralvenius WT, et al. J Exp Med. 2023 Nov 6;220(11):e20222105. doi: 10.1084/jem.20222105. Epub 2023 Aug 29. J Exp Med. 2023. PMID: 37642942 Free PMC article.
APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia.
Sienski G, Narayan P, Bonner JM, Kory N, Boland S, Arczewska AA, Ralvenius WT, Akay L, Lockshin E, He L, Milo B, Graziosi A, Baru V, Lewis CA, Kellis M, Sabatini DM, Tsai LH, Lindquist S. Sienski G, et al. Among authors: ralvenius wt. Sci Transl Med. 2021 Mar 3;13(583):eaaz4564. doi: 10.1126/scitranslmed.aaz4564. Sci Transl Med. 2021. PMID: 33658354 Free PMC article.
Mice lacking spinal α2GABAA receptors: Altered GABAergic neurotransmission, diminished GABAergic antihyperalgesia, and potential compensatory mechanisms preventing a hyperalgesic phenotype.
Tudeau L, Acuña MA, Albisetti GW, Neumann E, Ralvenius WT, Scheurer L, Poe M, Cook JM, Johannssen HC, Zeilhofer HU. Tudeau L, et al. Among authors: ralvenius wt. Brain Res. 2020 Aug 15;1741:146889. doi: 10.1016/j.brainres.2020.146889. Epub 2020 May 18. Brain Res. 2020. PMID: 32439345 Free article.
Modeling Alzheimer's disease with iPSC-derived brain cells.
Penney J, Ralvenius WT, Tsai LH. Penney J, et al. Among authors: ralvenius wt. Mol Psychiatry. 2020 Jan;25(1):148-167. doi: 10.1038/s41380-019-0468-3. Epub 2019 Aug 7. Mol Psychiatry. 2020. PMID: 31391546 Free PMC article. Review.
Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors.
Ralvenius WT, Neumann E, Pagani M, Acuña MA, Wildner H, Benke D, Fischer N, Rostaher A, Schwager S, Detmar M, Frauenknecht K, Aguzzi A, Hubbs JL, Rudolph U, Favrot C, Zeilhofer HU. Ralvenius WT, et al. Nat Commun. 2018 Aug 13;9(1):3230. doi: 10.1038/s41467-018-05709-0. Nat Commun. 2018. PMID: 30104684 Free PMC article.
21 results