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A study of the structure-activity relationship of GABA(A)-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis.
Han D, Holger Försterling F, Li X, Deschamps JR, Parrish D, Cao H, Rallapalli S, Clayton T, Teng Y, Majumder S, Sankar S, Roth BL, Sieghart W, Furtmuller R, Rowlett JK, Weed MR, Cook JM. Han D, et al. Among authors: rallapalli s. Bioorg Med Chem. 2008 Oct 1;16(19):8853-62. doi: 10.1016/j.bmc.2008.08.072. Epub 2008 Sep 2. Bioorg Med Chem. 2008. PMID: 18790643 Free PMC article.
Search for α3β₂/₃γ2 subtype selective ligands that are stable on human liver microsomes.
Namjoshi OA, Wang ZJ, Rallapalli SK, Johnson EM Jr, Johnson YT, Ng H, Ramerstorfer J, Varagic Z, Sieghart W, Majumder S, Roth BL, Rowlett JK, Cook JM. Namjoshi OA, et al. Among authors: rallapalli sk. Bioorg Med Chem. 2013 Jan 1;21(1):93-101. doi: 10.1016/j.bmc.2012.10.057. Epub 2012 Nov 15. Bioorg Med Chem. 2013. PMID: 23218469 Free PMC article.
The differential role of alpha1- and alpha5-containing GABA(A) receptors in mediating diazepam effects on spontaneous locomotor activity and water-maze learning and memory in rats.
Savić MM, Milinković MM, Rallapalli S, Clayton T Sr, Joksimović S, Van Linn M, Cook JM. Savić MM, et al. Among authors: rallapalli s. Int J Neuropsychopharmacol. 2009 Oct;12(9):1179-93. doi: 10.1017/S1461145709000108. Epub 2009 Mar 6. Int J Neuropsychopharmacol. 2009. PMID: 19265570 Free PMC article.
PWZ-029, an inverse agonist selective for α₅ GABAA receptors, improves object recognition, but not water-maze memory in normal and scopolamine-treated rats.
Milić M, Timić T, Joksimović S, Biawat P, Rallapalli S, Divljaković J, Radulović T, Cook JM, Savić MM. Milić M, et al. Among authors: rallapalli s. Behav Brain Res. 2013 Mar 15;241:206-13. doi: 10.1016/j.bbr.2012.12.016. Epub 2012 Dec 20. Behav Brain Res. 2013. PMID: 23261875 Free PMC article.
Insights into functional pharmacology of α₁ GABA(A) receptors: how much does partial activation at the benzodiazepine site matter?
Joksimović S, Varagic Z, Kovačević J, Van Linn M, Milić M, Rallapalli S, Timić T, Sieghart W, Cook JM, Savić MM. Joksimović S, et al. Among authors: rallapalli s. Psychopharmacology (Berl). 2013 Nov;230(1):113-23. doi: 10.1007/s00213-013-3143-4. Epub 2013 May 18. Psychopharmacology (Berl). 2013. PMID: 23685860 Free PMC article.
42 results