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The HMG-CoA reductase inhibitor, pravastatin, prevents the development of monocrotaline-induced pulmonary hypertension in the rat through reduction of endothelial cell apoptosis and overexpression of eNOS.
Guerard P, Rakotoniaina Z, Goirand F, Rochette L, Dumas M, Lirussi F, Bardou M. Guerard P, et al. Among authors: rakotoniaina z. Naunyn Schmiedebergs Arch Pharmacol. 2006 Sep;373(6):401-14. doi: 10.1007/s00210-006-0082-1. Epub 2006 Aug 1. Naunyn Schmiedebergs Arch Pharmacol. 2006. PMID: 16896805
The protective effect of HMG-CoA reductase inhibitors against monocrotaline-induced pulmonary hypertension in the rat might not be a class effect: comparison of pravastatin and atorvastatin.
Rakotoniaina Z, Guerard P, Lirussi F, Goirand F, Rochette L, Dumas M, Bardou M. Rakotoniaina Z, et al. Naunyn Schmiedebergs Arch Pharmacol. 2006 Dec;374(3):195-206. doi: 10.1007/s00210-006-0112-z. Epub 2006 Nov 11. Naunyn Schmiedebergs Arch Pharmacol. 2006. PMID: 17102939