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Identification of diphenylurea derivatives as novel endocytosis inhibitors that demonstrate broad-spectrum activity against SARS-CoV-2 and influenza A virus both in vitro and in vivo.
Kumar N, Taily IM, Singh C, Kumar S, Rajmani RS, Chakraborty D, Sharma A, Singh P, Thakur KG, Varadarajan R, Ringe RP, Banerjee P, Banerjee I. Kumar N, et al. Among authors: rajmani rs. PLoS Pathog. 2023 May 1;19(5):e1011358. doi: 10.1371/journal.ppat.1011358. eCollection 2023 May. PLoS Pathog. 2023. PMID: 37126530 Free PMC article.
Picolinic acid is a broad-spectrum inhibitor of enveloped virus entry that restricts SARS-CoV-2 and influenza A virus in vivo.
Narayan R, Sharma M, Yadav R, Biji A, Khatun O, Kaur S, Kanojia A, Joy CM, Rajmani R, Sharma PR, Jeyasankar S, Rani P, Shandil RK, Narayanan S, Rao DC, Satchidanandam V, Das S, Agarwal R, Tripathi S. Narayan R, et al. Cell Rep Med. 2023 Aug 15;4(8):101127. doi: 10.1016/j.xcrm.2023.101127. Epub 2023 Jul 17. Cell Rep Med. 2023. PMID: 37463584 Free PMC article.
PARP1 inhibition protects mice against Japanese encephalitis virus infection.
Desingu PA, Mishra S, Dindi L, Srinivasan S, Rajmani RS, Ravi V, Tamta AK, Raghu S, Murugasamy K, Pandit AS, Sundaresan NR. Desingu PA, et al. Among authors: rajmani rs. Cell Rep. 2023 Sep 26;42(9):113103. doi: 10.1016/j.celrep.2023.113103. Epub 2023 Sep 6. Cell Rep. 2023. PMID: 37676769 Free article.
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