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Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo.
Jayaraman M, Ansell SM, Mui BL, Tam YK, Chen J, Du X, Butler D, Eltepu L, Matsuda S, Narayanannair JK, Rajeev KG, Hafez IM, Akinc A, Maier MA, Tracy MA, Cullis PR, Madden TD, Manoharan M, Hope MJ. Jayaraman M, et al. Among authors: rajeev kg. Angew Chem Int Ed Engl. 2012 Aug 20;51(34):8529-33. doi: 10.1002/anie.201203263. Epub 2012 Jul 10. Angew Chem Int Ed Engl. 2012. PMID: 22782619 Free PMC article.
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs.
Soutschek J, Akinc A, Bramlage B, Charisse K, Constien R, Donoghue M, Elbashir S, Geick A, Hadwiger P, Harborth J, John M, Kesavan V, Lavine G, Pandey RK, Racie T, Rajeev KG, Röhl I, Toudjarska I, Wang G, Wuschko S, Bumcrot D, Koteliansky V, Limmer S, Manoharan M, Vornlocher HP. Soutschek J, et al. Among authors: rajeev kg. Nature. 2004 Nov 11;432(7014):173-8. doi: 10.1038/nature03121. Nature. 2004. PMID: 15538359 Free article.
Silencing of microRNAs in vivo with 'antagomirs'.
Krützfeldt J, Rajewsky N, Braich R, Rajeev KG, Tuschl T, Manoharan M, Stoffel M. Krützfeldt J, et al. Among authors: rajeev kg. Nature. 2005 Dec 1;438(7068):685-9. doi: 10.1038/nature04303. Epub 2005 Oct 30. Nature. 2005. PMID: 16258535
Specificity, duplex degradation and subcellular localization of antagomirs.
Krützfeldt J, Kuwajima S, Braich R, Rajeev KG, Pena J, Tuschl T, Manoharan M, Stoffel M. Krützfeldt J, et al. Among authors: rajeev kg. Nucleic Acids Res. 2007;35(9):2885-92. doi: 10.1093/nar/gkm024. Epub 2007 Apr 16. Nucleic Acids Res. 2007. PMID: 17439965 Free PMC article.
Mechanisms and optimization of in vivo delivery of lipophilic siRNAs.
Wolfrum C, Shi S, Jayaprakash KN, Jayaraman M, Wang G, Pandey RK, Rajeev KG, Nakayama T, Charrise K, Ndungo EM, Zimmermann T, Koteliansky V, Manoharan M, Stoffel M. Wolfrum C, et al. Among authors: rajeev kg. Nat Biotechnol. 2007 Oct;25(10):1149-57. doi: 10.1038/nbt1339. Epub 2007 Sep 16. Nat Biotechnol. 2007. PMID: 17873866
Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme.
Li F, Pallan PS, Maier MA, Rajeev KG, Mathieu SL, Kreutz C, Fan Y, Sanghvi J, Micura R, Rozners E, Manoharan M, Egli M. Li F, et al. Among authors: rajeev kg. Nucleic Acids Res. 2007;35(19):6424-38. doi: 10.1093/nar/gkm664. Epub 2007 Sep 18. Nucleic Acids Res. 2007. PMID: 17881374 Free PMC article.
Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits.
DiFiglia M, Sena-Esteves M, Chase K, Sapp E, Pfister E, Sass M, Yoder J, Reeves P, Pandey RK, Rajeev KG, Manoharan M, Sah DW, Zamore PD, Aronin N. DiFiglia M, et al. Among authors: rajeev kg. Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17204-9. doi: 10.1073/pnas.0708285104. Epub 2007 Oct 16. Proc Natl Acad Sci U S A. 2007. PMID: 17940007 Free PMC article.
60 results