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Cross-species analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion.
Purcell RH, Sefik E, Werner E, King AT, Mosley TJ, Merritt-Garza ME, Chopra P, McEachin ZT, Karne S, Raj N, Vaglio BJ, Sullivan D, Firestein BL, Tilahun K, Robinette MI, Warren ST, Wen Z, Faundez V, Sloan SA, Bassell GJ, Mulle JG. Purcell RH, et al. Among authors: raj n. Sci Adv. 2023 Aug 18;9(33):eadh0558. doi: 10.1126/sciadv.adh0558. Epub 2023 Aug 16. Sci Adv. 2023. PMID: 37585521 Free PMC article.
Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36.
McEachin ZT, Gendron TF, Raj N, García-Murias M, Banerjee A, Purcell RH, Ward PJ, Todd TW, Merritt-Garza ME, Jansen-West K, Hales CM, García-Sobrino T, Quintáns B, Holler CJ, Taylor G, San Millán B, Teijeira S, Yamashita T, Ohkubo R, Boulis NM, Xu C, Wen Z, Streichenberger N; Neuro–CEB Neuropathology Network; Fogel BL, Kukar T, Abe K, Dickson DW, Arias M, Glass JD, Jiang J, Tansey MG, Sobrido MJ, Petrucelli L, Rossoll W, Bassell GJ. McEachin ZT, et al. Among authors: raj n. Neuron. 2020 Jul 22;107(2):292-305.e6. doi: 10.1016/j.neuron.2020.04.011. Epub 2020 May 5. Neuron. 2020. PMID: 32375063 Free PMC article.
Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns.
Das Sharma S, Pal R, Reddy BK, Selvaraj BT, Raj N, Samaga KK, Srinivasan DJ, Ornelas L, Sareen D, Livesey MR, Bassell GJ, Svendsen CN, Kind PC, Chandran S, Chattarji S, Wyllie DJA. Das Sharma S, et al. Among authors: raj n. Mol Autism. 2020 Jun 19;11(1):52. doi: 10.1186/s13229-020-00351-4. Mol Autism. 2020. PMID: 32560741 Free PMC article.
RNA-mediated toxicity in C9orf72 ALS and FTD.
McEachin ZT, Parameswaran J, Raj N, Bassell GJ, Jiang J. McEachin ZT, et al. Among authors: raj n. Neurobiol Dis. 2020 Nov;145:105055. doi: 10.1016/j.nbd.2020.105055. Epub 2020 Aug 21. Neurobiol Dis. 2020. PMID: 32829028 Free PMC article. Review.
Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis.
Raj N, McEachin ZT, Harousseau W, Zhou Y, Zhang F, Merritt-Garza ME, Taliaferro JM, Kalinowska M, Marro SG, Hales CM, Berry-Kravis E, Wolf-Ochoa MW, Martinez-Cerdeño V, Wernig M, Chen L, Klann E, Warren ST, Jin P, Wen Z, Bassell GJ. Raj N, et al. Cell Rep. 2021 Apr 13;35(2):108991. doi: 10.1016/j.celrep.2021.108991. Cell Rep. 2021. PMID: 33852833 Free PMC article.
A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies.
Kang Y, Zhou Y, Li Y, Han Y, Xu J, Niu W, Li Z, Liu S, Feng H, Huang W, Duan R, Xu T, Raj N, Zhang F, Dou J, Xu C, Wu H, Bassell GJ, Warren ST, Allen EG, Jin P, Wen Z. Kang Y, et al. Among authors: raj n. Nat Neurosci. 2021 Oct;24(10):1377-1391. doi: 10.1038/s41593-021-00913-6. Epub 2021 Aug 19. Nat Neurosci. 2021. PMID: 34413513 Free PMC article.
374 results