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Mitochondrial creatine sensitivity is lost in the D2.mdx model of Duchenne muscular dystrophy and rescued by the mitochondrial-enhancing compound Olesoxime.
Bellissimo CA, Delfinis LJ, Hughes MC, Turnbull PC, Gandhi S, DiBenedetto SN, Rahman FA, Tadi P, Amaral CA, Dehghani A, Cobley JN, Quadrilatero J, Schlattner U, Perry CGR. Bellissimo CA, et al. Among authors: rahman fa. Am J Physiol Cell Physiol. 2023 May 1;324(5):C1141-C1157. doi: 10.1152/ajpcell.00377.2022. Epub 2023 Jan 23. Am J Physiol Cell Physiol. 2023. PMID: 36689672 Free article.
Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress.
Delfinis LJ, Bellissimo CA, Gandhi S, DiBenedetto SN, Garibotti MC, Thuhan AK, Tsitkanou S, Rosa-Caldwell ME, Rahman FA, Cheng AJ, Wiggs MP, Schlattner U, Quadrilatero J, Greene NP, Perry CG. Delfinis LJ, et al. Among authors: rahman fa. JCI Insight. 2022 Dec 22;7(24):e155147. doi: 10.1172/jci.insight.155147. JCI Insight. 2022. PMID: 36346680 Free PMC article.
49 results