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Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index.
Shen W, De Hoyos CL, Migawa MT, Vickers TA, Sun H, Low A, Bell TA 3rd, Rahdar M, Mukhopadhyay S, Hart CE, Bell M, Riney S, Murray SF, Greenlee S, Crooke RM, Liang XH, Seth PP, Crooke ST. Shen W, et al. Among authors: rahdar m. Nat Biotechnol. 2019 Jun;37(6):640-650. doi: 10.1038/s41587-019-0106-2. Epub 2019 Apr 29. Nat Biotechnol. 2019. PMID: 31036929
Synthetic CRISPR RNA-Cas9-guided genome editing in human cells.
Rahdar M, McMahon MA, Prakash TP, Swayze EE, Bennett CF, Cleveland DW. Rahdar M, et al. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):E7110-7. doi: 10.1073/pnas.1520883112. Epub 2015 Nov 16. Proc Natl Acad Sci U S A. 2015. PMID: 26589814 Free PMC article.
Gene editing: not just for translation anymore.
McMahon MA, Rahdar M, Porteus M. McMahon MA, et al. Among authors: rahdar m. Nat Methods. 2011 Dec 28;9(1):28-31. doi: 10.1038/nmeth.1811. Nat Methods. 2011. PMID: 22205513 No abstract available.
TALENs Facilitate Single-step Seamless SDF Correction of F508del CFTR in Airway Epithelial Submucosal Gland Cell-derived CF-iPSCs.
Suzuki S, Sargent RG, Illek B, Fischer H, Esmaeili-Shandiz A, Yezzi MJ, Lee A, Yang Y, Kim S, Renz P, Qi Z, Yu J, Muench MO, Beyer AI, Guimarães AO, Ye L, Chang J, Fine EJ, Cradick TJ, Bao G, Rahdar M, Porteus MH, Shuto T, Kai H, Kan YW, Gruenert DC. Suzuki S, et al. Among authors: rahdar m. Mol Ther Nucleic Acids. 2016 Jan 5;5(1):e273. doi: 10.1038/mtna.2015.43. Mol Ther Nucleic Acids. 2016. PMID: 26730810 Free PMC article.
49 results