Ragno R - Search Results

1

Human estrogen receptor α antagonists, part 2: Synthesis driven by rational design, in vitro antiproliferative, and in vivo anticancer evaluation of innovative coumarin-related antiestrogens as breast cancer suppressants.

Kurtanović N, Tomašević N, Matić S, Mitrović MM, Kostić DA, Sabatino M, Antonini L, Ragno R, Mladenović M. Kurtanović N, et al. Among authors: ragno r. Eur J Med Chem. 2022 Jan 5;227:113869. doi: 10.1016/j.ejmech.2021.113869. Epub 2021 Sep 29. Eur J Med Chem. 2022. PMID: 34710747

2

Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.

Mai A, Sbardella G, Artico M, Ragno R, Massa S, Novellino E, Greco G, Lavecchia A, Musiu C, La Colla M, Murgioni C, La Colla P, Loddo R. Mai A, et al. Among authors: ragno r. J Med Chem. 2001 Aug 2;44(16):2544-54. doi: 10.1021/jm010853h. J Med Chem. 2001. PMID: 11472208

3

Synthesis, biological evaluation, and binding mode of novel 1-[2-(diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles targeted at the HIV-1 reverse transcriptase.

Silvestri R, Artico M, De Martino G, Ragno R, Massa S, Loddo R, Murgioni C, Loi AG, La Colla P, Pani A. Silvestri R, et al. Among authors: ragno r. J Med Chem. 2002 Apr 11;45(8):1567-76. doi: 10.1021/jm010904a. J Med Chem. 2002. PMID: 11931611

4

Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation.

Mai A, Massa S, Ragno R, Esposito M, Sbardella G, Nocca G, Scatena R, Jesacher F, Loidl P, Brosch G. Mai A, et al. Among authors: ragno r. J Med Chem. 2002 Apr 25;45(9):1778-84. doi: 10.1021/jm011088+. J Med Chem. 2002. PMID: 11960489

5

3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-alkylamides as a new class of synthetic histone deacetylase inhibitors. 1. Design, synthesis, biological evaluation, and binding mode studies performed through three different docking procedures.

Mai A, Massa S, Ragno R, Cerbara I, Jesacher F, Loidl P, Brosch G. Mai A, et al. Among authors: ragno r. J Med Chem. 2003 Feb 13;46(4):512-24. doi: 10.1021/jm021070e. J Med Chem. 2003. PMID: 12570373

6

Computer-aided design, synthesis, and anti-HIV-1 activity in vitro of 2-alkylamino-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as novel potent non-nucleoside reverse transcriptase inhibitors, also active against the Y181C variant.

Ragno R, Mai A, Sbardella G, Artico M, Massa S, Musiu C, Mura M, Marturana F, Cadeddu A, La Colla P. Ragno R, et al. J Med Chem. 2004 Feb 12;47(4):928-34. doi: 10.1021/jm0309856. J Med Chem. 2004. PMID: 14761194

7

3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity.

Mai A, Massa S, Cerbara I, Valente S, Ragno R, Bottoni P, Scatena R, Loidl P, Brosch G. Mai A, et al. Among authors: ragno r. J Med Chem. 2004 Feb 26;47(5):1098-109. doi: 10.1021/jm030990+. J Med Chem. 2004. PMID: 14971890

8

3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 3. Discovery of novel lead compounds through structure-based drug design and docking studies.

Ragno R, Mai A, Massa S, Cerbara I, Valente S, Bottoni P, Scatena R, Jesacher F, Loidl P, Brosch G. Ragno R, et al. J Med Chem. 2004 Mar 11;47(6):1351-9. doi: 10.1021/jm031036f. J Med Chem. 2004. PMID: 14998325

9

HIV-reverse transcriptase inhibition: inclusion of ligand-induced fit by cross-docking studies.

Ragno R, Frasca S, Manetti F, Brizzi A, Massa S. Ragno R, et al. J Med Chem. 2005 Jan 13;48(1):200-12. doi: 10.1021/jm0493921. J Med Chem. 2005. PMID: 15634014

10

Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors.

Mai A, Massa S, Lavu S, Pezzi R, Simeoni S, Ragno R, Mariotti FR, Chiani F, Camilloni G, Sinclair DA. Mai A, et al. Among authors: ragno r. J Med Chem. 2005 Dec 1;48(24):7789-95. doi: 10.1021/jm050100l. J Med Chem. 2005. PMID: 16302818

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