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Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function.
Jami S, Deuis JR, Klasfauseweh T, Cheng X, Kurdyukov S, Chung F, Okorokov AL, Li S, Zhang J, Cristofori-Armstrong B, Israel MR, Ju RJ, Robinson SD, Zhao P, Ragnarsson L, Andersson Å, Tran P, Schendel V, McMahon KL, Tran HNT, Chin YK, Zhu Y, Liu J, Crawford T, Purushothamvasan S, Habib AM, Andersson DA, Rash LD, Wood JN, Zhao J, Stehbens SJ, Mobli M, Leffler A, Jiang D, Cox JJ, Waxman SG, Dib-Hajj SD, Neely GG, Durek T, Vetter I. Jami S, et al. Among authors: ragnarsson l. Nat Commun. 2023 Apr 28;14(1):2442. doi: 10.1038/s41467-023-37963-2. Nat Commun. 2023. PMID: 37117223 Free PMC article.
Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species.
Muttenthaler M, Andersson Å, Vetter I, Menon R, Busnelli M, Ragnarsson L, Bergmayr C, Arrowsmith S, Deuis JR, Chiu HS, Palpant NJ, O'Brien M, Smith TJ, Wray S, Neumann ID, Gruber CW, Lewis RJ, Alewood PF. Muttenthaler M, et al. Among authors: ragnarsson l. Sci Signal. 2017 Dec 5;10(508):eaan3398. doi: 10.1126/scisignal.aan3398. Sci Signal. 2017. PMID: 29208680 Free PMC article.
The Tarantula Venom Peptide Eo1a Binds to the Domain II S3-S4 Extracellular Loop of Voltage-Gated Sodium Channel NaV1.8 to Enhance Activation.
Deuis JR, Ragnarsson L, Robinson SD, Dekan Z, Chan L, Jin AH, Tran P, McMahon KL, Li S, Wood JN, Cox JJ, King GF, Herzig V, Vetter I. Deuis JR, et al. Among authors: ragnarsson l. Front Pharmacol. 2022 Jan 14;12:789570. doi: 10.3389/fphar.2021.789570. eCollection 2021. Front Pharmacol. 2022. PMID: 35095499 Free PMC article.
38 results