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TGS1 mediates 2,2,7-trimethyl guanosine capping of the human telomerase RNA to direct telomerase dependent telomere maintenance.
Buemi V, Schillaci O, Santorsola M, Bonazza D, Broccia PV, Zappone A, Bottin C, Dell'Omo G, Kengne S, Cacchione S, Raffa GD, Piazza S, di Fagagna FD, Benetti R, Cortale M, Zanconati F, Del Sal G, Schoeftner S. Buemi V, et al. Among authors: raffa gd. Nat Commun. 2022 Apr 28;13(1):2302. doi: 10.1038/s41467-022-29907-z. Nat Commun. 2022. PMID: 35484160 Free PMC article.
A role for Separase in telomere protection.
Cipressa F, Morciano P, Bosso G, Mannini L, Galati A, Raffa GD, Cacchione S, Musio A, Cenci G. Cipressa F, et al. Among authors: raffa gd. Nat Commun. 2016 Jan 18;7:10405. doi: 10.1038/ncomms10405. Nat Commun. 2016. PMID: 26778495 Free PMC article.
The S-adenosylmethionine analog sinefungin inhibits the trimethylguanosine synthase TGS1 to promote telomerase activity and telomere lengthening.
Galati A, Scatolini L, Micheli E, Bavasso F, Cicconi A, Maccallini P, Chen L, Roake CM, Schoeftner S, Artandi SE, Gatti M, Cacchione S, Raffa GD. Galati A, et al. Among authors: raffa gd. FEBS Lett. 2022 Jan;596(1):42-52. doi: 10.1002/1873-3468.14240. Epub 2021 Dec 5. FEBS Lett. 2022. PMID: 34817067 Free article.
AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance.
Burla R, Carcuro M, Raffa GD, Galati A, Raimondo D, Rizzo A, La Torre M, Micheli E, Ciapponi L, Cenci G, Cundari E, Musio A, Biroccio A, Cacchione S, Gatti M, Saggio I. Burla R, et al. Among authors: raffa gd. PLoS Genet. 2015 Jun 25;11(6):e1005167. doi: 10.1371/journal.pgen.1005167. eCollection 2015 Jun. PLoS Genet. 2015. PMID: 26110528 Free PMC article.
27 results