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Small-Molecule Inhibitors Targeting Lipolysis in Human Adipocytes.
Grabner GF, Guttenberger N, Mayer N, Migglautsch-Sulzer AK, Lembacher-Fadum C, Fawzy N, Bulfon D, Hofer P, Züllig T, Hartig L, Kulminskaya N, Chalhoub G, Schratter M, Radner FPW, Preiss-Landl K, Masser S, Lass A, Zechner R, Gruber K, Oberer M, Breinbauer R, Zimmermann R. Grabner GF, et al. Among authors: radner fpw. J Am Chem Soc. 2022 Apr 13;144(14):6237-6250. doi: 10.1021/jacs.1c10836. Epub 2022 Apr 1. J Am Chem Soc. 2022. PMID: 35362954 Free PMC article.
Adipose triglyceride lipase plays a key role in the supply of the working muscle with fatty acids.
Schoiswohl G, Schweiger M, Schreiber R, Gorkiewicz G, Preiss-Landl K, Taschler U, Zierler KA, Radner FP, Eichmann TO, Kienesberger PC, Eder S, Lass A, Haemmerle G, Alsted TJ, Kiens B, Hoefler G, Zechner R, Zimmermann R. Schoiswohl G, et al. J Lipid Res. 2010 Mar;51(3):490-9. doi: 10.1194/jlr.M001073. Epub 2009 Nov 25. J Lipid Res. 2010. PMID: 19965578 Free PMC article.
Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58).
Radner FP, Streith IE, Schoiswohl G, Schweiger M, Kumari M, Eichmann TO, Rechberger G, Koefeler HC, Eder S, Schauer S, Theussl HC, Preiss-Landl K, Lass A, Zimmermann R, Hoefler G, Zechner R, Haemmerle G. Radner FP, et al. J Biol Chem. 2010 Mar 5;285(10):7300-11. doi: 10.1074/jbc.M109.081877. Epub 2009 Dec 18. J Biol Chem. 2010. PMID: 20023287 Free PMC article.
Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance.
Taschler U, Radner FP, Heier C, Schreiber R, Schweiger M, Schoiswohl G, Preiss-Landl K, Jaeger D, Reiter B, Koefeler HC, Wojciechowski J, Theussl C, Penninger JM, Lass A, Haemmerle G, Zechner R, Zimmermann R. Taschler U, et al. J Biol Chem. 2011 May 20;286(20):17467-77. doi: 10.1074/jbc.M110.215434. Epub 2011 Mar 23. J Biol Chem. 2011. PMID: 21454566 Free PMC article.
ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1.
Haemmerle G, Moustafa T, Woelkart G, Büttner S, Schmidt A, van de Weijer T, Hesselink M, Jaeger D, Kienesberger PC, Zierler K, Schreiber R, Eichmann T, Kolb D, Kotzbeck P, Schweiger M, Kumari M, Eder S, Schoiswohl G, Wongsiriroj N, Pollak NM, Radner FP, Preiss-Landl K, Kolbe T, Rülicke T, Pieske B, Trauner M, Lass A, Zimmermann R, Hoefler G, Cinti S, Kershaw EE, Schrauwen P, Madeo F, Mayer B, Zechner R. Haemmerle G, et al. Nat Med. 2011 Aug 21;17(9):1076-85. doi: 10.1038/nm.2439. Nat Med. 2011. PMID: 21857651 Free PMC article.
Functional cardiac lipolysis in mice critically depends on comparative gene identification-58.
Zierler KA, Jaeger D, Pollak NM, Eder S, Rechberger GN, Radner FPW, Woelkart G, Kolb D, Schmidt A, Kumari M, Preiss-Landl K, Pieske B, Mayer B, Zimmermann R, Lass A, Zechner R, Haemmerle G. Zierler KA, et al. Among authors: radner fpw. J Biol Chem. 2013 Apr 5;288(14):9892-9904. doi: 10.1074/jbc.M112.420620. Epub 2013 Feb 14. J Biol Chem. 2013. PMID: 23413028 Free PMC article.
Fasting-induced G0/G1 switch gene 2 and FGF21 expression in the liver are under regulation of adipose tissue derived fatty acids.
Jaeger D, Schoiswohl G, Hofer P, Schreiber R, Schweiger M, Eichmann TO, Pollak NM, Poecher N, Grabner GF, Zierler KA, Eder S, Kolb D, Radner FP, Preiss-Landl K, Lass A, Zechner R, Kershaw EE, Haemmerle G. Jaeger D, et al. J Hepatol. 2015 Aug;63(2):437-45. doi: 10.1016/j.jhep.2015.02.035. Epub 2015 Feb 27. J Hepatol. 2015. PMID: 25733154 Free PMC article.
33 results