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The rapidly evolving role of cryo-EM in drug design.
Wigge C, Stefanovic A, Radjainia M. Wigge C, et al. Among authors: radjainia m. Drug Discov Today Technol. 2020 Dec;38:91-102. doi: 10.1016/j.ddtec.2020.12.003. Epub 2021 Jan 11. Drug Discov Today Technol. 2020. PMID: 34895645 Review.
The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Pang SS, Bayly-Jones C, Radjainia M, Spicer BA, Law RHP, Hodel AW, Parsons ES, Ekkel SM, Conroy PJ, Ramm G, Venugopal H, Bird PI, Hoogenboom BW, Voskoboinik I, Gambin Y, Sierecki E, Dunstone MA, Whisstock JC. Pang SS, et al. Among authors: radjainia m. Nat Commun. 2019 Sep 19;10(1):4288. doi: 10.1038/s41467-019-12279-2. Nat Commun. 2019. PMID: 31537793 Free PMC article.
Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor.
Liang YL, Khoshouei M, Deganutti G, Glukhova A, Koole C, Peat TS, Radjainia M, Plitzko JM, Baumeister W, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Wootten D, Sexton PM. Liang YL, et al. Among authors: radjainia m. Nature. 2018 Sep;561(7724):492-497. doi: 10.1038/s41586-018-0535-y. Epub 2018 Sep 12. Nature. 2018. PMID: 30209400 Free PMC article.
Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain.
Chi G, Liang Q, Sridhar A, Cowgill JB, Sader K, Radjainia M, Qian P, Castro-Hartmann P, Venkaya S, Singh NK, McKinley G, Fernandez-Cid A, Mukhopadhyay SMM, Burgess-Brown NA, Delemotte L, Covarrubias M, Dürr KL. Chi G, et al. Among authors: radjainia m. Nat Commun. 2022 Jul 15;13(1):4087. doi: 10.1038/s41467-022-29594-w. Nat Commun. 2022. PMID: 35840580 Free PMC article.
Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex.
Liang YL, Khoshouei M, Glukhova A, Furness SGB, Zhao P, Clydesdale L, Koole C, Truong TT, Thal DM, Lei S, Radjainia M, Danev R, Baumeister W, Wang MW, Miller LJ, Christopoulos A, Sexton PM, Wootten D. Liang YL, et al. Among authors: radjainia m. Nature. 2018 Mar 1;555(7694):121-125. doi: 10.1038/nature25773. Epub 2018 Feb 21. Nature. 2018. PMID: 29466332
Volta phase plate cryo-EM of the small protein complex Prx3.
Khoshouei M, Radjainia M, Phillips AJ, Gerrard JA, Mitra AK, Plitzko JM, Baumeister W, Danev R. Khoshouei M, et al. Among authors: radjainia m. Nat Commun. 2016 Jan 28;7:10534. doi: 10.1038/ncomms10534. Nat Commun. 2016. PMID: 26817416 Free PMC article.
Phase-plate cryo-EM structure of a class B GPCR-G-protein complex.
Liang YL, Khoshouei M, Radjainia M, Zhang Y, Glukhova A, Tarrasch J, Thal DM, Furness SGB, Christopoulos G, Coudrat T, Danev R, Baumeister W, Miller LJ, Christopoulos A, Kobilka BK, Wootten D, Skiniotis G, Sexton PM. Liang YL, et al. Among authors: radjainia m. Nature. 2017 Jun 1;546(7656):118-123. doi: 10.1038/nature22327. Epub 2017 Apr 24. Nature. 2017. PMID: 28437792 Free PMC article.
The extracellular protein factor Epf from Streptococcus pyogenes is a cell surface adhesin that binds to cells through an N-terminal domain containing a carbohydrate-binding module.
Linke C, Siemens N, Oehmcke S, Radjainia M, Law RH, Whisstock JC, Baker EN, Kreikemeyer B. Linke C, et al. Among authors: radjainia m. J Biol Chem. 2012 Nov 2;287(45):38178-89. doi: 10.1074/jbc.M112.376434. Epub 2012 Sep 12. J Biol Chem. 2012. PMID: 22977243 Free PMC article.
31 results