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Mitochondria-targeted catalase reduces abnormal APP processing, amyloid β production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension.
Mao P, Manczak M, Calkins MJ, Truong Q, Reddy TP, Reddy AP, Shirendeb U, Lo HH, Rabinovitch PS, Reddy PH. Mao P, et al. Among authors: rabinovitch ps. Hum Mol Genet. 2012 Jul 1;21(13):2973-90. doi: 10.1093/hmg/dds128. Epub 2012 Apr 5. Hum Mol Genet. 2012. PMID: 22492996 Free PMC article.
Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance.
Lee HY, Choi CS, Birkenfeld AL, Alves TC, Jornayvaz FR, Jurczak MJ, Zhang D, Woo DK, Shadel GS, Ladiges W, Rabinovitch PS, Santos JH, Petersen KF, Samuel VT, Shulman GI. Lee HY, et al. Among authors: rabinovitch ps. Cell Metab. 2010 Dec 1;12(6):668-74. doi: 10.1016/j.cmet.2010.11.004. Cell Metab. 2010. PMID: 21109199 Free PMC article.
Extension of murine life span by overexpression of catalase targeted to mitochondria.
Schriner SE, Linford NJ, Martin GM, Treuting P, Ogburn CE, Emond M, Coskun PE, Ladiges W, Wolf N, Van Remmen H, Wallace DC, Rabinovitch PS. Schriner SE, et al. Among authors: rabinovitch ps. Science. 2005 Jun 24;308(5730):1909-11. doi: 10.1126/science.1106653. Epub 2005 May 5. Science. 2005. PMID: 15879174
Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging.
Dai DF, Santana LF, Vermulst M, Tomazela DM, Emond MJ, MacCoss MJ, Gollahon K, Martin GM, Loeb LA, Ladiges WC, Rabinovitch PS. Dai DF, et al. Among authors: rabinovitch ps. Circulation. 2009 Jun 2;119(21):2789-97. doi: 10.1161/CIRCULATIONAHA.108.822403. Epub 2009 May 18. Circulation. 2009. PMID: 19451351 Free PMC article.
Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure.
Dai DF, Johnson SC, Villarin JJ, Chin MT, Nieves-Cintrón M, Chen T, Marcinek DJ, Dorn GW 2nd, Kang YJ, Prolla TA, Santana LF, Rabinovitch PS. Dai DF, et al. Among authors: rabinovitch ps. Circ Res. 2011 Apr 1;108(7):837-46. doi: 10.1161/CIRCRESAHA.110.232306. Epub 2011 Feb 10. Circ Res. 2011. PMID: 21311045 Free PMC article.
323 results