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Modified quantitative insulin sensitivity check index is better correlated to hyperinsulinemic glucose clamp than other fasting-based index of insulin sensitivity in different insulin-resistant states.
Rabasa-Lhoret R, Bastard JP, Jan V, Ducluzeau PH, Andreelli F, Guebre F, Bruzeau J, Louche-Pellissier C, MaItrepierre C, Peyrat J, Chagné J, Vidal H, Laville M. Rabasa-Lhoret R, et al. J Clin Endocrinol Metab. 2003 Oct;88(10):4917-23. doi: 10.1210/jc.2002-030316. J Clin Endocrinol Metab. 2003. PMID: 14557474 Clinical Trial.
FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction.
Bravard A, Lefai E, Meugnier E, Pesenti S, Disse E, Vouillarmet J, Peretti N, Rabasa-Lhoret R, Laville M, Vidal H, Rieusset J. Bravard A, et al. Diabetes. 2011 Jan;60(1):258-68. doi: 10.2337/db10-0281. Epub 2010 Oct 13. Diabetes. 2011. PMID: 20943749 Free PMC article.
392 results