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oFlowSeq: a quantitative approach to identify protein coding mutations affecting cell type enrichment using mosaic CRISPR-Cas9 edited cerebral organoids.
Dawes P, Murray LF, Olson MN, Barton NJ, Smullen M, Suresh M, Yan G, Zhang Y, Fernandez-Fontaine A, English J, Uddin M, Pak C, Church GM, Chan Y, Lim ET. Dawes P, et al. Hum Genet. 2023 Aug;142(8):1281-1291. doi: 10.1007/s00439-023-02534-4. Epub 2023 Mar 6. Hum Genet. 2023. PMID: 36877372 Free PMC article.
Massively targeted evaluation of therapeutic CRISPR off-targets in cells.
Pan X, Qu K, Yuan H, Xiang X, Anthon C, Pashkova L, Liang X, Han P, Corsi GI, Xu F, Liu P, Zhong J, Zhou Y, Ma T, Jiang H, Liu J, Wang J, Jessen N, Bolund L, Yang H, Xu X, Church GM, Gorodkin J, Lin L, Luo Y. Pan X, et al. Nat Commun. 2022 Jul 13;13(1):4049. doi: 10.1038/s41467-022-31543-6. Nat Commun. 2022. PMID: 35831290 Free PMC article.
Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder.
Lim ET, Chan Y, Dawes P, Guo X, Erdin S, Tai DJC, Liu S, Reichert JM, Burns MJ, Chan YK, Chiang JJ, Meyer K, Zhang X, Walsh CA, Yankner BA, Raychaudhuri S, Hirschhorn JN, Gusella JF, Talkowski ME, Church GM. Lim ET, et al. Nat Commun. 2022 Jun 10;13(1):3243. doi: 10.1038/s41467-022-30968-3. Nat Commun. 2022. PMID: 35688811 Free PMC article.
72 results