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Page 1
Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation.
Park KC, Crump NT, Louwman N, Krywawych S, Cheong YJ, Vendrell I, Gill EK, Gunadasa-Rohling M, Ford KL, Hauton D, Fournier M, Pires E, Watson L, Roseman G, Holder J, Koschinski A, Carnicer R, Curtis MK, Zaccolo M, Hulikova A, Fischer R, Kramer HB, McCullagh JSO, Trefely S, Milne TA, Swietach P. Park KC, et al. Nat Cardiovasc Res. 2023 Dec;2(12):1221-1245. doi: 10.1038/s44161-023-00365-0. Epub 2023 Nov 23. Nat Cardiovasc Res. 2023. PMID: 38500966 Free PMC article.
Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart.
Hulikova A, Park KC, Loonat AA, Gunadasa-Rohling M, Curtis MK, Chung YJ, Wilson A, Carr CA, Trafford AW, Fournier M, Moshnikova A, Andreev OA, Reshetnyak YK, Riley PR, Smart N, Milne TA, Crump NT, Swietach P. Hulikova A, et al. Basic Res Cardiol. 2022 Mar 31;117(1):17. doi: 10.1007/s00395-022-00924-9. Basic Res Cardiol. 2022. PMID: 35357563 Free PMC article.
Acidic environments trigger intracellular H+-sensing FAK proteins to re-balance sarcolemmal acid-base transporters and auto-regulate cardiomyocyte pH.
Wilson AD, Richards MA, Curtis MK, Gunadasa-Rohling M, Monterisi S, Loonat AA, Miller JJ, Ball V, Lewis A, Tyler DJ, Moshnikova A, Andreev OA, Reshetnyak YK, Carr C, Swietach P. Wilson AD, et al. Cardiovasc Res. 2022 Nov 10;118(14):2946-2959. doi: 10.1093/cvr/cvab364. Cardiovasc Res. 2022. PMID: 34897412 Free PMC article.
SGLT2 inhibitors and the cardiac Na+/H+ exchanger-1: the plot thickens.
Chung YJ, Park KC, Tokar S, Eykyn TR, Fuller W, Pavlovic D, Swietach P, Shattock MJ. Chung YJ, et al. Cardiovasc Res. 2021 Dec 17;117(14):2702-2704. doi: 10.1093/cvr/cvab184. Cardiovasc Res. 2021. PMID: 34051094 Free PMC article. No abstract available.
Oxidation of Protein Kinase A Regulatory Subunit PKARIα Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Lysosomal-Triggered Calcium Release.
Simon JN, Vrellaku B, Monterisi S, Chu SM, Rawlings N, Lomas O, Marchal GA, Waithe D, Syeda F, Gajendragadkar PR, Jayaram R, Sayeed R, Channon KM, Fabritz L, Swietach P, Zaccolo M, Eaton P, Casadei B. Simon JN, et al. Circulation. 2021 Feb 2;143(5):449-465. doi: 10.1161/CIRCULATIONAHA.120.046761. Epub 2020 Nov 13. Circulation. 2021. PMID: 33185461 Free PMC article.
17 results