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2013 8
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Inhibition of thrombin on endothelium enhances recruitment of regulatory T cells during IRI and when combined with adoptive Treg transfer, significantly protects against acute tissue injury and prolongs allograft survival.
Peng Q, Nowocin A, Ratnasothy K, Smith RA, Smyth LA, Lechler RI, Dorling A, Lombardi G. Peng Q, et al. Front Immunol. 2023 Jan 30;13:980462. doi: 10.3389/fimmu.2022.980462. eCollection 2022. Front Immunol. 2023. PMID: 36793549 Free PMC article.
Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells.
Chauss D, Freiwald T, McGregor R, Yan B, Wang L, Nova-Lamperti E, Kumar D, Zhang Z, Teague H, West EE, Vannella KM, Ramos-Benitez MJ, Bibby J, Kelly A, Malik A, Freeman AF, Schwartz DM, Portilla D, Chertow DS, John S, Lavender P, Kemper C, Lombardi G, Mehta NN, Cooper N, Lionakis MS, Laurence A, Kazemian M, Afzali B. Chauss D, et al. Nat Immunol. 2022 Jan;23(1):62-74. doi: 10.1038/s41590-021-01080-3. Epub 2021 Nov 11. Nat Immunol. 2022. PMID: 34764490 Free PMC article.
Chimeric antigen receptor-modified human regulatory T cells that constitutively express IL-10 maintain their phenotype and are potently suppressive.
Mohseni YR, Saleem A, Tung SL, Dudreuilh C, Lang C, Peng Q, Volpe A, Adigbli G, Cross A, Hester J, Farzaneh F, Scotta C, Lechler RI, Issa F, Fruhwirth GO, Lombardi G. Mohseni YR, et al. Eur J Immunol. 2021 Oct;51(10):2522-2530. doi: 10.1002/eji.202048934. Epub 2021 Aug 8. Eur J Immunol. 2021. PMID: 34320225 Free PMC article.
PD-L1 signaling on human memory CD4+ T cells induces a regulatory phenotype.
Fanelli G, Romano M, Nova-Lamperti E, Werner Sunderland M, Nerviani A, Scottà C, Bombardieri M, Quezada SA, Sacks SH, Noelle RJ, Pitzalis C, Lechler RI, Lombardi G, Becker PD. Fanelli G, et al. PLoS Biol. 2021 Apr 26;19(4):e3001199. doi: 10.1371/journal.pbio.3001199. eCollection 2021 Apr. PLoS Biol. 2021. PMID: 33901179 Free PMC article.
Spatiotemporal in vivo tracking of polyclonal human regulatory T cells (Tregs) reveals a role for innate immune cells in Treg transplant recruitment.
Jacob J, Nadkarni S, Volpe A, Peng Q, Tung SL, Hannen RF, Mohseni YR, Scotta C, Marelli-Berg FM, Lechler RI, Smyth LA, Fruhwirth GO, Lombardi G. Jacob J, et al. Mol Ther Methods Clin Dev. 2020 Dec 10;20:324-336. doi: 10.1016/j.omtm.2020.12.003. eCollection 2021 Mar 12. Mol Ther Methods Clin Dev. 2020. PMID: 33511246 Free PMC article.
Feasibility, long-term safety, and immune monitoring of regulatory T cell therapy in living donor kidney transplant recipients.
Harden PN, Game DS, Sawitzki B, Van der Net JB, Hester J, Bushell A, Issa F, Brook MO, Alzhrani A, Schlickeiser S, Scotta C, Petchey W, Streitz M, Blancho G, Tang Q, Markmann J, Lechler RI, Roberts ISD, Friend PJ, Hilton R, Geissler EK, Wood KJ, Lombardi G. Harden PN, et al. Am J Transplant. 2021 Apr;21(4):1603-1611. doi: 10.1111/ajt.16395. Epub 2021 Feb 2. Am J Transplant. 2021. PMID: 33171020 Free PMC article. Clinical Trial.
59 results