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Blood-brain barrier dysfunction in aging induces hyperactivation of TGFβ signaling and chronic yet reversible neural dysfunction.
Senatorov VV Jr, Friedman AR, Milikovsky DZ, Ofer J, Saar-Ashkenazy R, Charbash A, Jahan N, Chin G, Mihaly E, Lin JM, Ramsay HJ, Moghbel A, Preininger MK, Eddings CR, Harrison HV, Patel R, Shen Y, Ghanim H, Sheng H, Veksler R, Sudmant PH, Becker A, Hart B, Rogawski MA, Dillin A, Friedman A, Kaufer D. Senatorov VV Jr, et al. Sci Transl Med. 2019 Dec 4;11(521):eaaw8283. doi: 10.1126/scitranslmed.aaw8283. Sci Transl Med. 2019. PMID: 31801886
Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood-brain barrier dysfunction.
Weissberg I, Wood L, Kamintsky L, Vazquez O, Milikovsky DZ, Alexander A, Oppenheim H, Ardizzone C, Becker A, Frigerio F, Vezzani A, Buckwalter MS, Huguenard JR, Friedman A, Kaufer D. Weissberg I, et al. Neurobiol Dis. 2015 Jun;78:115-25. doi: 10.1016/j.nbd.2015.02.029. Epub 2015 Mar 30. Neurobiol Dis. 2015. PMID: 25836421 Free PMC article.
Blood-brain barrier imaging in human neuropathologies.
Veksler R, Shelef I, Friedman A. Veksler R, et al. Arch Med Res. 2014 Nov;45(8):646-52. doi: 10.1016/j.arcmed.2014.11.016. Epub 2014 Nov 29. Arch Med Res. 2014. PMID: 25453223 Free PMC article. Review.
Losartan prevents acquired epilepsy via TGF-β signaling suppression.
Bar-Klein G, Cacheaux LP, Kamintsky L, Prager O, Weissberg I, Schoknecht K, Cheng P, Kim SY, Wood L, Heinemann U, Kaufer D, Friedman A. Bar-Klein G, et al. Ann Neurol. 2014 Jun;75(6):864-75. doi: 10.1002/ana.24147. Epub 2014 May 28. Ann Neurol. 2014. PMID: 24659129 Free PMC article.