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Restoration of virulence in the attenuated Candid#1 vaccine virus requires reversion at both positions 168 and 427 in the envelope glycoprotein GPC.
J Virol. 2024 Apr 16;98(4):e0011224. doi: 10.1128/jvi.00112-24. Epub 2024 Mar 20.
J Virol. 2024.
PMID: 38506509
Free PMC article.
Second-Generation Live-Attenuated Candid#1 Vaccine Virus Resists Reversion and Protects against Lethal Junín Virus Infection in Guinea Pigs.
Gowen BB, Hickerson BT, York J, Westover JB, Sefing EJ, Bailey KW, Wandersee L, Nunberg JH.
Gowen BB, et al.
J Virol. 2021 Jun 24;95(14):e0039721. doi: 10.1128/JVI.00397-21. Epub 2021 Jun 24.
J Virol. 2021.
PMID: 33952638
Free PMC article.
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