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Page 1
SAMHD1 enhances immunoglobulin hypermutation by promoting transversion mutation.
Thientosapol ES, Bosnjak D, Durack T, Stevanovski I, van Geldermalsen M, Holst J, Jahan Z, Shepard C, Weninger W, Kim B, Brink R, Jolly CJ. Thientosapol ES, et al. Proc Natl Acad Sci U S A. 2018 May 8;115(19):4921-4926. doi: 10.1073/pnas.1719771115. Epub 2018 Apr 18. Proc Natl Acad Sci U S A. 2018. PMID: 29669924 Free PMC article.
SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemia.
Johansson P, Klein-Hitpass L, Choidas A, Habenberger P, Mahboubi B, Kim B, Bergmann A, Scholtysik R, Brauser M, Lollies A, Siebert R, Zenz T, Dührsen U, Küppers R, Dürig J. Johansson P, et al. Blood Cancer J. 2018 Jan 19;8(1):11. doi: 10.1038/s41408-017-0036-5. Blood Cancer J. 2018. PMID: 29352181 Free PMC article. Clinical Trial.
Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.
Baldauf HM, Stegmann L, Schwarz SM, Ambiel I, Trotard M, Martin M, Burggraf M, Lenzi GM, Lejk H, Pan X, Fregoso OI, Lim ES, Abraham L, Nguyen LA, Rutsch F, König R, Kim B, Emerman M, Fackler OT, Keppler OT. Baldauf HM, et al. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2729-2734. doi: 10.1073/pnas.1613635114. Epub 2017 Feb 22. Proc Natl Acad Sci U S A. 2017. PMID: 28228523 Free PMC article.
A G1-like state allows HIV-1 to bypass SAMHD1 restriction in macrophages.
Mlcochova P, Sutherland KA, Watters SA, Bertoli C, de Bruin RA, Rehwinkel J, Neil SJ, Lenzi GM, Kim B, Khwaja A, Gage MC, Georgiou C, Chittka A, Yona S, Noursadeghi M, Towers GJ, Gupta RK. Mlcochova P, et al. EMBO J. 2017 Mar 1;36(5):604-616. doi: 10.15252/embj.201696025. Epub 2017 Jan 25. EMBO J. 2017. PMID: 28122869 Free PMC article.
34 results