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Page 1
Mitochondrial uncouplers induce proton leak by activating AAC and UCP1.
Bertholet AM, Natale AM, Bisignano P, Suzuki J, Fedorenko A, Hamilton J, Brustovetsky T, Kazak L, Garrity R, Chouchani ET, Brustovetsky N, Grabe M, Kirichok Y. Bertholet AM, et al. Nature. 2022 Jun;606(7912):180-187. doi: 10.1038/s41586-022-04747-5. Epub 2022 May 25. Nature. 2022. PMID: 35614225 Free PMC article.
Mitochondrial H+ Leak and Thermogenesis.
Bertholet AM, Kirichok Y. Bertholet AM, et al. Annu Rev Physiol. 2022 Feb 10;84:381-407. doi: 10.1146/annurev-physiol-021119-034405. Epub 2021 Nov 10. Annu Rev Physiol. 2022. PMID: 34758268 Free PMC article. Review.
Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers.
Chatterjee N, Pazarentzos E, Mayekar MK, Gui P, Allegakoen DV, Hrustanovic G, Olivas V, Lin L, Verschueren E, Johnson JR, Hofree M, Yan JJ, Newton BW, Dollen JV, Earnshaw CH, Flanagan J, Chan E, Asthana S, Ideker T, Wu W, Suzuki J, Barad BA, Kirichok Y, Fraser JS, Weiss WA, Krogan NJ, Tulpule A, Sabnis AJ, Bivona TG. Chatterjee N, et al. Cell Rep. 2019 Aug 27;28(9):2317-2330.e8. doi: 10.1016/j.celrep.2019.07.063. Cell Rep. 2019. PMID: 31461649 Free PMC article.