R35 GM122523/GM/NIGMS NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2017	2
2018	5
2019	5
2020	4
2021	8
2022	5
2023	3
2024	0

1

Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration.

Jones AC, Kornev AP, Weng JH, Manning G, Taylor SS, Newton AC. Jones AC, et al. Biochem J. 2023 Aug 30;480(16):1299-1316. doi: 10.1042/BCJ20220397. Biochem J. 2023. PMID: 37551632 Free PMC article.

2

Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness.

Gu L, Zhu Y, Watari K, Lee M, Liu J, Perez S, Thai M, Mayfield JE, Zhang B, Cunha E Rocha K, Li F, Kim LC, Jones AC, Wierzbicki IH, Liu X, Newton AC, Kisseleva T, Lee JH, Ying W, Gonzalez DJ, Saltiel AR, Simon MC, Karin M. Gu L, et al. Cell Metab. 2023 Jun 6;35(6):1009-1021.e9. doi: 10.1016/j.cmet.2023.03.021. Epub 2023 Apr 20. Cell Metab. 2023. PMID: 37084733 Free PMC article.

3

Protein kinase C showcases allosteric control: activation of LRRK1.

Tovell H, Newton AC. Tovell H, et al. Biochem J. 2023 Feb 14;480(3):219-223. doi: 10.1042/BCJ20220507. Biochem J. 2023. PMID: 36762701 Free PMC article.

4

Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model.

Lordén G, Wozniak JM, Doré K, Dozier LE, Cates-Gatto C, Patrick GN, Gonzalez DJ, Roberts AJ, Tanzi RE, Newton AC. Lordén G, et al. Nat Commun. 2022 Nov 23;13(1):7200. doi: 10.1038/s41467-022-34679-7. Nat Commun. 2022. PMID: 36418293 Free PMC article.

5

Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition.

Pilo CA, Baffi TR, Kornev AP, Kunkel MT, Malfavon M, Chen DH, Rossitto LA, Chen DX, Huang LC, Longman C, Kannan N, Raskind WH, Gonzalez DJ, Taylor SS, Gorrie G, Newton AC. Pilo CA, et al. Sci Signal. 2022 Sep 27;15(753):eabk1147. doi: 10.1126/scisignal.abk1147. Epub 2022 Sep 27. Sci Signal. 2022. PMID: 36166510 Free PMC article.

6

Two Sides of the Same Coin: Protein Kinase C γ in Cancer and Neurodegeneration.

Pilo CA, Newton AC. Pilo CA, et al. Front Cell Dev Biol. 2022 Jun 21;10:929510. doi: 10.3389/fcell.2022.929510. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35800893 Free PMC article. Review.

7

Protein kinase C: release from quarantine by mTORC2.

Baffi TR, Newton AC. Baffi TR, et al. Trends Biochem Sci. 2022 Jun;47(6):518-530. doi: 10.1016/j.tibs.2022.03.003. Epub 2022 Mar 28. Trends Biochem Sci. 2022. PMID: 35361526 Free PMC article. Review.

8

Conventional protein kinase C in the brain: repurposing cancer drugs for neurodegenerative treatment?

Lordén G, Newton AC. Lordén G, et al. Neuronal Signal. 2021 Oct 8;5(4):NS20210036. doi: 10.1042/NS20210036. eCollection 2021 Dec. Neuronal Signal. 2021. PMID: 34737895 Free PMC article. Review.

9

mTOR Regulation of AGC Kinases: New Twist to an Old Tail.

Baffi TR, Newton AC. Baffi TR, et al. Mol Pharmacol. 2022 Apr;101(4):213-218. doi: 10.1124/molpharm.121.000310. Epub 2021 Jun 21. Mol Pharmacol. 2022. PMID: 34155089 Free PMC article. Review.

10

mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif.

Baffi TR, Lordén G, Wozniak JM, Feichtner A, Yeung W, Kornev AP, King CC, Del Rio JC, Limaye AJ, Bogomolovas J, Gould CM, Chen J, Kennedy EJ, Kannan N, Gonzalez DJ, Stefan E, Taylor SS, Newton AC. Baffi TR, et al. Sci Signal. 2021 Apr 13;14(678):eabe4509. doi: 10.1126/scisignal.abe4509. Sci Signal. 2021. PMID: 33850054 Free PMC article.

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