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Oxidized analogs of Di(1H-indol-3-yl)methyl-4-substituted benzenes are NR4A1-dependent UPR inducers with potent and safe anti-cancer activity.
Sanchez M, Xia Z, Rico-Bautista E, Cao X, Cuddy M, Castro DJ, Correa RG, Chen L, Yu J, Bobkov A, Ruvolo V, Andreeff M, Oshima RG, Matsuzawa SI, Reed JC, Zhang XK, Hansel D, Wolf DA, Dawson MI. Sanchez M, et al. Oncotarget. 2018 May 18;9(38):25057-25074. doi: 10.18632/oncotarget.25285. eCollection 2018 May 18. Oncotarget. 2018. PMID: 29861853 Free PMC article.