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Dengue virus serotypic replacement of NS3 protease or helicase domain causes chimeric viral attenuation but can be recovered by a compensated mutation at helicase domain or NS2B, respectively.
J Virol. 2023 Aug 31;97(8):e0085423. doi: 10.1128/jvi.00854-23. Epub 2023 Aug 9.
J Virol. 2023.
PMID: 37555662
Free PMC article.
Flavivirus proteases: The viral Achilles heel to prevent future pandemics.
Teramoto T, Choi KH, Padmanabhan R.
Teramoto T, et al.
Antiviral Res. 2023 Feb;210:105516. doi: 10.1016/j.antiviral.2022.105516. Epub 2022 Dec 29.
Antiviral Res. 2023.
PMID: 36586467
Free PMC article.
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